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Flexible and navigable suction ureteral access sheath (FANS) is a potential game changer in flexible ureteroscopy (FURS). The influence of sheath size on outcomes needs research. The primary aim was to analyze 30-day single stage stone free status (SFS), zero fragment rate (ZFR) and complications when using 10/12Fr sheaths vis a vis other sheath sizes. The global FANS research group published the 30-day outcomes in patients who underwent FANS and reasoned this can be a potential game changer. We included 295 patients from this anonymized dataset with division into two groups: Group 1 (Smaller sheath) - 10/12Fr FANS, and Group 2 (Larger sheath) - 11/13Fr or 12/14Fr sheaths. Stone volume was similar between both groups (median 1320 mm, p = 0.88). Ureteroscopy and total operative time was longer in the smaller sheath group (35 vs. 32 min, p = 0.02 and 50 vs. 45 min, p = 0.001, respectively). While 30-day computed tomography SFS (100% stone free or single residual fragment ≤ 2 mm) were not significantly different (96% vs. 95%, p > 0.99), ZFR (100% stone-free) was better with smaller sheaths (68% vs. 53%, p = 0.02). There was no difference in postoperative complication rates, and no sepsis in both groups. Urologists should consider individualizing appropriate sheath size in normal adult kidneys. Sheath size did not affect complication rates, risk of perioperative injury to the pelvicalyceal system or ureteric injury, but smaller FANS sheaths had similar high SFS. The ZFR with smaller sheaths was better, but this needs to be validated. These smaller sheath outcomes need to be balanced with longer ureteroscopy time, operative time, reach to the lower pole, ease of suction and visibility during lithotripsy. Large volume studies in different types of pelvicalyceal anatomy can determine if indeed smaller FANS is the best choice in FURS.
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http://dx.doi.org/10.1007/s00240-024-01662-4 | DOI Listing |
PLoS Pathog
September 2025
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, California, United States of America.
The discovery of the endosymbiotic bacteria Wolbachia as an obligate symbiont of. filarial nematodes has led to antibiotic-based treatments for filarial diseases. While lab.
View Article and Find Full Text PDFJBJS Essent Surg Tech
September 2025
Division of Hand and Reconstructive Microsurgery, Department of Orthopedics, Olympia Hospital & Research Centre, Trichy, Tamilnadu, India.
Background: Hemi-hamate osteochondral grafting is a surgical technique that is utilized to reconstruct the proximal interphalangeal (PIP) joint in cases of unstable dorsal fracture-dislocation with >50% articular surface involvement. However, hemi-hamate osteochondral grafting can be technically challenging, has been reported to have various technical modifications, and can lead to complications such as overstuffing of the joint. This surgical technique article describes successful PIP joint reconstruction with use of a hemi-capitate osteochondral graft, which may offer a viable alternative to hemi-hamate osteochondral graft.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Physics, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN 46202, USA.
Conventional TiO₂ nanoparticle syntheses rely on high temperatures, toxic reagents and multi-step routes that impede scalability and sustainability. Here, we deliver the first green synthesis of TiO₂ nanoparticles (TiO₂ NPs) using polysaccharide- (42 mg GE g) and phenolic-rich (78 mg GAE g) Pinus patula leaf extract. GC-MS and LC-MS fingerprinting identify terpenoids, flavonoids and phenolic glycosides acting as simultaneous reducing, capping and stabilizing agents.
View Article and Find Full Text PDFPain Med
September 2025
Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, PA.
Objective: Introduced in 1970s, Spinal Cord Stimulator (SCS) devices have played a crucial role in managing a wide range of complex and refractory chronic pain, particularly back/leg pain as well as neuropathic pain. Currently, two primary types of leads, cylindrical and paddle leads, are prevalent in pain management. While both effectively alleviate pain, cylindrical leads, due to their small size, are susceptible to movement and migration as well as a smaller surface area for coverage, leading to device displacement and failure to provide pain relief.
View Article and Find Full Text PDFJ Endourol
September 2025
Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Percutaneous nephrolithotomy (PCNL) technique trends have shifted toward smaller caliber access sheaths, leading to a varied array of miniPCNL (mPCNL) systems. Urinary biomarkers have been validated as noninvasive direct markers of renal cellular injury. Our objective was to assess changes in biomarkers levels in the perioperative setting, comparing mPCNL suction (s-mPCNL), non-suction (ns-mPCNL), and standard PCNL (sPCNL) systems.
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