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We present the self-organizing nervous system (SoNS), a robot swarm architecture based on self-organized hierarchy. The SoNS approach enables robots to autonomously establish, maintain, and reconfigure dynamic multilevel system architectures. For example, a robot swarm consisting of independent robots could transform into a single -robot SoNS and then into several independent smaller SoNSs, where each SoNS uses a temporary and dynamic hierarchy. Leveraging the SoNS approach, we showed that sensing, actuation, and decision-making can be coordinated in a locally centralized way without sacrificing the benefits of scalability, flexibility, and fault tolerance, for which swarm robotics is usually studied. In several proof-of-concept robot missions-including binary decision-making and search and rescue-we demonstrated that the capabilities of the SoNS approach greatly advance the state of the art in swarm robotics. The missions were conducted with a real heterogeneous aerial-ground robot swarm, using a custom-developed quadrotor platform. We also demonstrated the scalability of the SoNS approach in swarms of up to 250 robots in a physics-based simulator and demonstrated several types of system fault tolerance in simulation and reality.
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http://dx.doi.org/10.1126/scirobotics.adl5161 | DOI Listing |
mSphere
September 2025
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA.
Apicomplexan AP2 (ApiAP2) family proteins are a family of transcription factors that are known to regulate gene expression in apicomplexan pathogens, including . In this study, we focused on TgAP2X-7, a member of the APiAP2 family that is predicted to be essential for fitness. Endogenous tagging of TgAP2X-7 followed by immunofluorescence analysis revealed that it's a cell cycle-regulated nuclear protein with peak expression in the G1 phase.
View Article and Find Full Text PDFGlob Health Action
December 2025
Institute for Global Health Sciences, University of California, San Francisco, CA, USA.
Background: Despite evidence that mothers-in-law (MILs) influence daughters-in-law's (DILs) fertility and family planning decisions in South Asia, emphasizing early fertility and male grandchildren, few reproductive health interventions engage MILs directly.
Objectives: We assessed the feasibility, acceptability, and qualitative impact of a reproductive health and life skill-based intervention on MILs in tribal Rajasthan, India, using a mixed-methods, single-group cluster pilot study.
Methods: We tested a light-touch four-session intervention delivered over 4 months to MILs of newly married women that covered MILs' health, conception, and communication with DILs and sons and addressed modern healthcare misconceptions, while challenging son preference and fertility norms.
Nucleic Acids Res
September 2025
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Poly(ADP-ribose) polymerases are critical enzymes contributing to regulation of numerous cellular processes, including DNA repair and chromatin remodelling. Within the PARP family, PARP1 and PARP2 primarily facilitate PARylation in the nucleus, particularly responding to genotoxic stress. The activity of PARPs is influenced by the nature of DNA damage and multiple protein partners, with HPF1 being the important one.
View Article and Find Full Text PDFTheor Appl Genet
September 2025
College of Horticulture, Shenyang Agricultural University, Shenyang, 110866, People's Republic of China.
Mutations in BrMYB31 were responsible for glossy phenotype, which was verified in two allelic mutants and gene silencing analysis. BrMYB31 regulated wax biosynthesis by modulating BrCER4 expression in Chinese cabbage. Plant cuticular wax plays a crucial role in resisting both biotic and abiotic stresses, but its deficiency is beneficial for improving the commercial properties of certain leafy vegetables.
View Article and Find Full Text PDFMol Ther Nucleic Acids
September 2025
Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
Loss-of-function mutations in the gene cause β-catenin deficiency, resulting in CTNNB1 syndrome, a rare neurodevelopmental disorder characterized by motor and cognitive impairments. Given the wide variety of mutations across and its dosage sensitivity, a mutation-independent therapeutic approach that preserves endogenous gene regulation is critically needed. This study introduces spliceosome-mediated RNA -splicing as a novel approach to restore β-catenin production.
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