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http://dx.doi.org/10.1001/jamapsychiatry.2024.3592 | DOI Listing |
Biology (Basel)
August 2025
Instituto de Investigaciones Farmacológicas, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Junín 956, piso 5, Buenos Aires C1113, Argentina.
Cocaine use remains a major public health concern, with rising global prevalence and a well-established profile of neurotoxicity and addictive potential. While the central nervous system has been the primary focus of cocaine research, emerging evidence indicates that cocaine also disrupts male reproductive physiology. In the testis, cocaine alters the endocrine microenvironment, induces cell-specific damage, and disrupts spermatogenesis.
View Article and Find Full Text PDFDev Psychobiol
September 2025
William James Centre for Research, ISPA University Institute of Psychological, Social and Life Sciences, Lisbon, Portugal.
This preregistered study investigated whether human paternal testosterone levels predicted fathers' time spent with their child and their involvement in childcare and household tasks. Additionally, we examined whether associations were mediated by fathers' attitudes toward child gender stereotypes. Associations were tested in an exploratory sample (n = 70, M = 6.
View Article and Find Full Text PDFJ Toxicol Sci
August 2025
Department of Toxicology, Showa Medical University Graduate School of Pharmacy.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is widely observed from childhood to adulthood and is treated with methylphenidate (MPH) as a first-line treatment. However, recent findings indicate that the paternal environment preceding conception may influence offspring health, potentially affecting subsequent generations. Moreover, we previously reported that MPH administration to sires reduced anxiety-related behaviors and induced memory impairments in the F1 generation.
View Article and Find Full Text PDFNucleic Acids Res
August 2025
Roche Pharma Research and Early Development, Neuroscience and Rare Disease discovery and translational area, Roche Innovation Center Basel, Basel 4070, Switzerland.
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal ubiquitin E3 ligase UBE3A, with no available treatment. Restoring UBE3A by downregulating the paternally cis-acting long noncoding antisense transcript (UBE3A-ATS) is a potentially disease modifying strategy. However, developing molecules targeting human UBE3A-ATS is challenging due to its selective expression in mature neurons and lack of sequence conservation across species.
View Article and Find Full Text PDFNutrients
August 2025
Department of Hygiene and Epidemiology, Faculty of Public Health, Medical University "Prof. Dr. Paraskev Stoyanov", 9000 Varna, Bulgaria.
: Optimal infant nutrition, particularly exclusive breastfeeding for the first 6 months, is crucial for both immediate and long-term health. The early years of life are essential for brain development due of the rapid maturation of social, emotional, cognitive and motor capacities. While benefits of breastfeeding are well established, its long-term impact on neurodevelopment remains underexplored.
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