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Biological sex estimation in forensic anthropology is a crucial topic, and the patella has shown promise in this regard due to its sexual dimorphism. This study uses 12 machine learning models for sex estimation based on three patellar measurements (maximum height, breadth, and thickness). Data was collected from 180 skeletons of a contemporary Italian population (83 males and 97 females) as well as from an independent sample of 21 forensic cases (13 males and 8 females). Statistical analyses indicated that each of the variables exhibited significant sexual dimorphism. To predict biological sex, the classifiers were built using 70% of a reference sample, then tested on the remaining 30% of the original sample and then tested again on the independent sample. The different classifiers generated accuracies varied between 0.85 and 0.91 on the reference sample and between 0.71 and 0.95 for the validation sample. SVM classifier stood out with the highest accuracy and seemed the best model for our study.This study contributes to the growing application of machine learning in forensic anthropology by being the first to apply such techniques to patellar measurements in an Italian population. It aims to enhance the accuracy and efficiency of biological sex estimation from the patella, building on promising results observed with other skeletal elements.
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http://dx.doi.org/10.1007/s00414-024-03359-0 | DOI Listing |
PLoS Med
September 2025
University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Background: Oral emtricitabine/tenofovir disoproxil fumarate (F/TDF) preexposure prophylaxis (PrEP) effectiveness against HIV acquisition highly depends on adherence. For men who have sex with men, a dosing study in the United States (US) population defined clinically meaningful tenofovir diphosphate (TFV-DP) thresholds in dried blood spots (DBS) based on the rounded 25th percentile for 2, 4, and 7 doses/week as 350, 700, and 1,250 fmol/punch. However, divergent efficacy results in the first generation randomized clinical trials of F/TDF PrEP among African women led to several hypotheses to question whether the pharmacology and adherence requirement for oral F/TDF PrEP may be different in cisgender women compared to what is already established for men.
View Article and Find Full Text PDFJ Alzheimers Dis
September 2025
Program for Research on Men's Health, Johns Hopkins Center for Health Disparities Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Odds ratios (OR) can overestimate risk when the prevalence of outcomes is more than 10%. We compared logistic and modified Poisson models in 5843 National Alzheimer's Coordinating Center decedents to examine associations of apolipoprotein () ε4, age at death, sex, and education with 7 neuropathologies. OR for neuritic plaques (6.
View Article and Find Full Text PDFMol Hum Reprod
September 2025
Department of Obstetrics and Gynecology, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Infertility impacts up to 17.5% of reproductive-aged couples worldwide. To aid in conception, many couples turn to assisted reproductive technology, such as IVF.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
September 2025
Obstructive sleep apnea (OSA), one of the most common sleep disorders globally, is closely linked to brain function. Resting-state electroencephalography (EEG), due to its convenience, cost-effectiveness, and high temporal resolution, serves as a valuable tool for exploring the human brain function. This study utilized a large cohort with 968 participants who joined in 15-minute daytime resting-state EEG acquisition and overnight polysomnography (PSG) monitoring.
View Article and Find Full Text PDFInt Urol Nephrol
September 2025
Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Purpose: Living donor kidney transplantation is a critical strategy to address the growing burden of end-stage kidney disease (ESKD) in Malaysia. Whilst living donation is generally safe, concerns remain regarding long-term donor outcomes. This study aimed to evaluate renal function and morbidity changes in living kidney donors 1 year post-donation, and to identify predictors of impaired kidney function.
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