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| http://dx.doi.org/10.1158/1541-7786.MCR-24-0859 | DOI Listing |
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Article Synopsis
- The CXCL family, important growth factors linked to tumor development, show abnormal expression levels in Epstein-Barr virus-associated gastric cancer (EBVaGC), making their study crucial for understanding prognosis.
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RETRACTED: CDX1 Expression Induced by CagA-Expressing Promotes Gastric Tumorigenesis.
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Center for Gastric Cancer, National Cancer Center, Goyang, Republic of Korea.
Intestinal-type gastric cancer often results from infection through intestinal metaplasia, a transdifferentiated premalignant phenotype. Because virulence factor CagA has been associated with aberrant expression of the transcription factor CDX1, which regulates intestinal differentiation, we explored its relationship with infection and function during gastric carcinogenesis in normal gastric epithelial cells and gastric cancer cell lines. Infection of HFE 145 cells with CagA increased expression of CDX1, as well as the epithelial-to-mesenchymal transition (EMT) markers Snail and Slug, increased invasion and migration, but those effects were not found in HFE 145 cells infected with CagA-deficient .
View Article and Find Full Text PDFExpression of carp-cdx1, a caudal homolog, in embryos of the carp, Cyprinus carpio.
Rouxs Arch Dev Biol
June 1995
Department of Experimental Animal Morphology and Cell Biology, Agricultural University of The Netherlands, Marijkeweg 40, 6709 PG, Wageningen, The Netherlands.
A carp caudal cDNA of 1.3 kb was cloned after screening an early segmentation stage cDNA library with a probe produced by PCR using conserved homeobox sequences as primers and genomic DNA as template. The homeobox gene was called carp-cdxl.
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