Splenic switch-off to assess for vasodilator non-responsiveness.

J Nucl Cardiol

Department of Medicine (Cardiology), Mount Sinai Morningside Hospital, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School ofMedicine at Mount Sinai, New York, USA; Department of Population Health Science and Policy, Blavatnik Family Women's Health Research Institute, Icahn School of

Published: November 2024


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nuclcard.2024.102067DOI Listing

Publication Analysis

Top Keywords

splenic switch-off
4
switch-off assess
4
assess vasodilator
4
vasodilator non-responsiveness
4
splenic
1
assess
1
vasodilator
1
non-responsiveness
1

Similar Publications

Splenic Switch-Off in 3D Adenosine Stress CMR Perfusion for Differentiating False-Negative from True-Negative Studies Identified by FFR.

J Cardiovasc Magn Reson

July 2025

Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, University of Zurich, Switzerland; Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Institute for Biomedical engineering, University and ETH Zurich, S

Background: False-negative cardiac magnetic resonance (CMR) perfusion results may arise from inadequate stress responses, even when patients exhibit an adequate clinical or heart-rate response to adenosine. This study aimed to explore the ability of qualitative and quantitative splenic switch-off markers to differentiate false-negative from true-negative adenosine stress-perfusion CMR findings, in a cohort where fractional flow reserve (FFR) was used to adjudicate lesion significance.

Methods: Patients with known or suspected coronary artery disease (CAD) from five centers underwent 3D adenosine stress perfusion CMR and coronary angiography with FFR.

View Article and Find Full Text PDF

AI-Derived Splenic Response in Cardiac PET Predicts Mortality: A Multi-Site Study.

medRxiv

June 2025

Departments of Medicine (Division of Artificial Intelligence in Medicine), Imaging, Cardiology, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Background: Inadequate pharmacologic stress may limit the diagnostic and prognostic accuracy of myocardial perfusion imaging (MPI). The splenic ratio (SR), a measure of stress adequacy, has emerged as a potential imaging biomarker.

Objectives: To evaluate the prognostic value of artificial intelligence (AI)-derived SR in a large multicenter Rb-PET cohort undergoing regadenoson stress testing.

View Article and Find Full Text PDF

Cardiac allograft vasculopathy and splenic switch-off: «Off we go»?

J Cardiol

August 2025

Royal Brompton and Harefield Hospitals, Guys' & St Thomas NHS Trust, London, UK; School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College University, London, UK.

View Article and Find Full Text PDF

Purpose: Splenic switch-off (SSO) is defined as a decrease in splenic radiotracer uptake following pharmacological stress. This study aimed to assess the clinical utility of SSO on adenosine triphosphate (ATP) N-ammonia positron emission tomography (PET) in patients without coronary artery disease (CAD).

Materials And Methods: We analyzed 63 patients (mean age, 67 ± 11 years; 34 males) who underwent ATP N-ammonia PET without significant CAD on invasive coronary angiography or cardiac computed tomography within 6 months.

View Article and Find Full Text PDF

Splenic switch-off to assess for vasodilator non-responsiveness.

J Nucl Cardiol

November 2024

Department of Medicine (Cardiology), Mount Sinai Morningside Hospital, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School ofMedicine at Mount Sinai, New York, USA; Department of Population Health Science and Policy, Blavatnik Family Women's Health Research Institute, Icahn School of

View Article and Find Full Text PDF