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http://dx.doi.org/10.1016/j.nuclcard.2024.102067 | DOI Listing |
J Cardiovasc Magn Reson
July 2025
Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, University of Zurich, Switzerland; Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Institute for Biomedical engineering, University and ETH Zurich, S
Background: False-negative cardiac magnetic resonance (CMR) perfusion results may arise from inadequate stress responses, even when patients exhibit an adequate clinical or heart-rate response to adenosine. This study aimed to explore the ability of qualitative and quantitative splenic switch-off markers to differentiate false-negative from true-negative adenosine stress-perfusion CMR findings, in a cohort where fractional flow reserve (FFR) was used to adjudicate lesion significance.
Methods: Patients with known or suspected coronary artery disease (CAD) from five centers underwent 3D adenosine stress perfusion CMR and coronary angiography with FFR.
medRxiv
June 2025
Departments of Medicine (Division of Artificial Intelligence in Medicine), Imaging, Cardiology, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Background: Inadequate pharmacologic stress may limit the diagnostic and prognostic accuracy of myocardial perfusion imaging (MPI). The splenic ratio (SR), a measure of stress adequacy, has emerged as a potential imaging biomarker.
Objectives: To evaluate the prognostic value of artificial intelligence (AI)-derived SR in a large multicenter Rb-PET cohort undergoing regadenoson stress testing.
J Cardiol
August 2025
Royal Brompton and Harefield Hospitals, Guys' & St Thomas NHS Trust, London, UK; School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College University, London, UK.
Jpn J Radiol
July 2025
Department of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan.
Purpose: Splenic switch-off (SSO) is defined as a decrease in splenic radiotracer uptake following pharmacological stress. This study aimed to assess the clinical utility of SSO on adenosine triphosphate (ATP) N-ammonia positron emission tomography (PET) in patients without coronary artery disease (CAD).
Materials And Methods: We analyzed 63 patients (mean age, 67 ± 11 years; 34 males) who underwent ATP N-ammonia PET without significant CAD on invasive coronary angiography or cardiac computed tomography within 6 months.
J Nucl Cardiol
November 2024
Department of Medicine (Cardiology), Mount Sinai Morningside Hospital, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School ofMedicine at Mount Sinai, New York, USA; Department of Population Health Science and Policy, Blavatnik Family Women's Health Research Institute, Icahn School of