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Meibomian Gland Dysfunction (MGD) and Dry Eye Disease (DED) comprise two of the most significant eye diseases, impacting millions of sufferers worldwide. Several etiological factors influence the early symptoms of DED. Early diagnosis and treatment of erectile dysfunction may significantly improve the Quality of Life (QoL) for people. The current study introduces the ESAE-ODNN, an improved stacked autoencoder-aided optimised deep neural network, as a new way to predict DED using feature selection (FS), feature extraction (FE), and classification. The approach described here is novel because it merges chaotic maps into FS, employs SLSTM-STSA for improved classification accuracy (CA), and optimizes with the adaptive quantum rotation of the Enhanced Quantum Bacterial Foraging Optimisation Algorithm (EQBFOA). The present study enhances prediction functions by extracting MGD-related features and complicated relationships from the DED dataset. To ensure essential feature identification, the ESAE minimizes irrelevant and redundant features. To predict the DED, the ESAE first applies FE and then implements an ODNN classifier. This method fine-tunes the ODNN framework to enhance the effectiveness of the classification. The proposed ESAE-ODNN classification system efficiently assists in the early diagnosis of DED. Combining advanced Deep Learning (DL) methods with optimization can help us understand MGD features better and sort the data with the best accuracy (96.34%). The experimental evaluation with relevant performance metrics indicates that the proposed method is efficient in diverse aspects: accurate identification, reduced complexity, and fine-tuned performance. The ESAE-ODNN's robustness in handling intricate feature indications and high-dimensional data outperforms the existing state-of-the-art techniques.
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http://dx.doi.org/10.1038/s41598-024-75518-7 | DOI Listing |
Behav Res Methods
September 2025
Czech Technical University in Prague, Faculty of Electrical Engineering, Department of Cybernetics, Prague, Czech Republic.
Automatic markerless estimation of infant posture and motion from ordinary videos carries great potential for movement studies "in the wild", facilitating understanding of motor development and massively increasing the chances of early diagnosis of disorders. There has been a rapid development of human pose estimation methods in computer vision, thanks to advances in deep learning and machine learning. However, these methods are trained on datasets that feature adults in different contexts.
View Article and Find Full Text PDFBiol Pharm Bull
September 2025
Computational and Biological Learning Laboratory, University of Cambridge, Cambridge CB21PZ, United Kingdom.
Neuroimaging in rodents holds promise for advancing our understanding of the central nervous system (CNS) mechanisms that underlie chronic pain. Employing two established, but pathophysiologically distinct rodent models of chronic pain, the aim of the present study was to characterize chronic pain-related functional changes with resting-state functional magnetic resonance imaging (fMRI). In Experiment 1, we report findings from Lewis rats 3 weeks after Complete Freund's adjuvant (CFA) injection into the knee joint (n = 16) compared with the controls (n = 14).
View Article and Find Full Text PDFSci Justice
September 2025
Department of Multidisciplinary Radiological Science, The Graduate School of Dongseo University, 47 Jurye-ro, Sasang-gu, Busan 47011, Republic of Korea. Electronic address:
The identification of deceased individuals is essential in forensic investigations, particularly when primary identification methods such as odontology, fingerprint, or DNA analysis are unavailable. In such cases, implanted medical devices may serve as supplementary identifiers for positive identification. This study proposes deep learning-based methods for the automatic detection of metallic implants in scout images acquired from computed tomography (CT).
View Article and Find Full Text PDFMethods
September 2025
School of Computer and Information Engineering, Henan University, Kaifeng, Henan, China; Henan Key Laboratory of Big Data Analysis and Processing, Henan University, Kaifeng, Henan, China. Electronic address:
Genomic selection (GS) is a breeding technique that utilizes genomic markers to predict the genetic potential of crops and animals. This approach holds significant promise for accelerating the improvement of agronomic traits and addressing food security challenges. While traditional breeding methods based on statistical or machine learning techniques have been useful in predicting traits for some crops, they often fail to capture the complex interactions between genotypes and phenotypes.
View Article and Find Full Text PDFJ Neurosci Methods
September 2025
Department of Computer Science and Engineering, IIT (ISM) Dhanbad, Dhanbad, 826004, Jharkhand, India. Electronic address:
Background: Interpretation of motor imagery (MI) in brain-computer interface (BCI) applications is largely driven by the use of electroencephalography (EEG) signals. However, precise classification in stroke patients remains challenging due to variability, non-stationarity, and abnormal EEG patterns.
New Methods: To address these challenges, an integrated architecture is proposed, combining multi-domain feature extraction with evolutionary optimization for enhanced EEG-based MI classification.