Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Biology can be viewed from both an organismal and a genic perspective. A good example is W.D. Hamilton's work on inclusive fitness and kin selection, which puts relatedness at the heart of our understanding of social behavior. Relatedness mediates how much an actor should value a specific behavior's effect on a relative compared to the cost incurred to itself. Despite its key explanatory role, relatedness is also a concept marred with misunderstanding. Part of the problem has been that the term has been used in different ways by different people. To help address this, we survey the history of how relatedness has been formally modeled, paying particular attention to how it is conceptualized from both a gene-centric and an organism-centric point of view.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694744 | PMC |
| http://dx.doi.org/10.1101/cshperspect.a041667 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Population substructure affects kinship testing in multi-ethnic areas of China.
Int J Legal Med
September 2025
West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Ren Min Nan Road 3-17, P.O.Box: 610041, Chengdu, P. R. China.
The likelihood ratio (LR) is a recommended metric for assessing the strength of genetic information in relationship testing, one of the most important tasks in forensic science. LR calculation incorporate population frequencies, which is affected by population substructure. This study utilized population frequency data from 18 short tandem repeat (STR) loci across 13 Chinese populations, encompassing both majority and minority ethnic groups.
View Article and Find Full Text PDFGenomic sequencing surveillance of patients colonized with vancomycin-resistant enterococci improves detection of healthcare-associated transmission.
BMC Glob Public Health
August 2025
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: Vancomycin-resistant enterococcal (VRE) infections pose significant challenges in healthcare. Transmission dynamics of VRE are complex, often involving patient colonization and subsequent transmission through various healthcare-associated vectors. We utilized a whole genome sequencing (WGS) surveillance program at our institution to better understand the contribution of clinical and colonizing isolates to VRE transmission.
View Article and Find Full Text PDFUtility of Polygenic Risk Scores in Families with Exceptional Longevity.
medRxiv
July 2025
Department of Neurology, Columbia University Irving Medical Center, 630W 168th street, New York City, New York, 10032, USA.
Introduction: Polygenic risk scores (PRS) have been used to assess an individual's risk for various diseases, including Alzheimer's disease (AD). This study applied the PRS approach to a cohort of families ascertained for healthy aging, that have shown a reduced risk of AD. Using the SNPs identified as significantly associated with AD in the study by Kunkle and colleagues, we examined the utility of PRS for predicting AD risk in a cohort ascertained for familial healthy aging.
View Article and Find Full Text PDFReducing redundancy and enhancing accuracy through a phylogenetically-informed microbial community metabolic modeling approach.
Bioinformatics
July 2025
Department of Mathematical Sciences, Sharif University of Technology, Tehran, 14588-89694, Iran.
Motivation: Metabolic modeling has emerged as a powerful tool for predicting community functions. However, current modeling approaches face significant challenges in balancing the metabolic trade-offs between individual and community-level growth. In this study, we investigated the effect of metabolic relatedness among taxa on growth rate calculations by merging related taxa based on their metabolic similarity, introducing this approach as PhyloCOBRA.
View Article and Find Full Text PDFIncreased Breeding Frequency Mitigates Inbreeding Depression in Peromyscus in Captivity.
Ecol Evol
July 2025
Department of Drug Discovery and Biomedical Sciences, College of Pharmacy University of South Carolina Columbia South Carolina USA.
Increased parental relatedness occurs in small wild populations and in closed colonies in captivity and reduces offspring fitness. A closed colony of is maintained as genetically diverse stock at the Peromyscus Genetic Stock Center since 1963. Breeding records are available for all the years of breeding in captivity, which allows evaluation of the breeding performance since the inception of the stock.
View Article and Find Full Text PDF