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Neuroprotective therapies for neonatal hypoxic-ischemic brain injury - a contemporary update.
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Department of Neonatology and Pediatric Intensive Care, Children's Hospital University of Bonn, 53127 Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany. Electronic address:
Neonatal encephalopathy of hypoxic-ischemic origin remains a leading cause of global neonatal mortality. Over the past decades, various neuroprotective strategies have been explored; however, therapeutic hypothermia remains the only clinically approved intervention to date. This review outlines emerging and adjunctive treatment modalities beyond therapeutic hypothermia and emphasizes the critical need for robust and reproducible translational research to bridge the gap between preclinical findings and clinical applications.
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Department of Operating Room & Anesthesia Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
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Intranasal Wharton's Jelly-Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic-Ischemic Brain Injury in Mice.
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Magnitude of Neonatal Hypothermia and Its Risk Factors Among Hospitalized Neonates in Southern Ethiopia.
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Department of Midwifery, College of Medicine & Health Sciences, Dilla University, Dilla, Ethiopia.
Newborn hypothermia is a critical global health challenge, particularly in low-resource settings, where it significantly contributes to neonatal morbidity and mortality. A mere one-degree drop in a newborn's body temperature can substantially increase the risk of death. Understanding hypothermia factors is key to developing strategies to reduce neonatal mortality.
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