Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
To ensure the effectiveness of traditional Chinese medicine (TCM) and drive the advancement of high-quality Chinese medicine, the establishment of a scientifically sound quality evaluation system is particularly important. The objective of this study was to develop a straightforward and practical comprehensive evaluation method for quality control of Xiaohuoluo Pills (XHLP) by employing diverse fingerprint technologies. Firstly, Fourier transform infrared spectroscopy fingerprint (FT-IRFP), ultraviolet spectral fingerprint (UVFP) and fusion fingerprints based on five-wavelength matched average fusion fingerprint (FWFFP) were established for 21 samples. Secondly, the Comprehensive Quantified Ratio Fingerprinting Method (CQRFM) was used to conduct a comprehensive evaluation of the fingerprint profiles of 21 batches of samples and the results showed that all samples met the quality requirements. Then to further evaluate the samples, the External Standard Method (ESM) was employed to measure the content of three indicator components in XHLP, and this was done with the intention of enhancing the quality control system of the samples. Furthermore, antioxidant activity was also measured, and a model for analyzing the relationship between antioxidant data and fingerprint information from the three spectra was established using Orthogonal Projection to Latent Structures (OPLS), resulting in an accurate spectral efficacy relationship diagram. In conclusion, this study utilized spectral and chromatography techniques to comprehensively assess the quality of XHLP, incorporating qualitative and quantitative aspects. Additionally, a correlation between spectral profiles and efficacy was established by evaluating the antioxidant capacity of the samples. This method offers valuable insights for quality control not only of XHLP but also for other TCM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4ay01029a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multienzyme Cascade Coimmobilization on ZIF-8-Coated Magnetic Nanoparticles for Efficient d-Allulose Synthesis.
J Agric Food Chem
September 2025
The State Key Laboratory of Food Science and Resources, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.
This study develops a multienzyme coimmobilization strategy on NTA-functionalized ZIF-8-coated magnetic nanoparticles (NZMNPs) for efficient d-allulose synthesis. Under optimized immobilization conditions (enzyme-to-carrier ratio: 1:50 w/w, 30 min immobilization), the system achieved an immobilization efficiency of 93.7% along with 107.
View Article and Find Full Text PDFRecent Advances in Gene Therapy for Hemophilia.
Clin Appl Thromb Hemost
September 2025
Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Hemophilia, an X-linked monogenic disorder, arises from mutations in the or genes, which encode clotting factor VIII (FVIII) or clotting factor IX (FIX), respectively. As a prominent hereditary coagulation disorder, hemophilia is clinically manifested by spontaneous hemorrhagic episodes. Severe cases may progress to complications such as stroke and arthropathy, significantly compromising patients' quality of life.
View Article and Find Full Text PDFPrevention of Incisional Hernias With Prophylactic Synthetic Mesh Placement During Stoma Reversal: A Randomized Clinical Trial.
JAMA Surg
September 2025
Department of Surgery, Meander Medical Center, Amersfoort, the Netherlands.
Importance: Stoma reversal is associated with few complications. However, recent studies show that 1 in 3 patients develop an incisional hernia, for which half of the patients receive surgical correction.
Objective: To investigate whether prophylactic synthetic mesh placement in the retromuscular space during stoma reversal reduces the rate of stomal site incisional hernias.
Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis: The PRIME Diagnostic Clinical Trial.
JAMA
September 2025
Division of Surgery and Interventional Science, UCL, London, United Kingdom.
Importance: Multiparametric magnetic resonance imaging (MRI), with or without prostate biopsy, has become the standard of care for diagnosing clinically significant prostate cancer. Resource capacity limits widespread adoption. Biparametric MRI, which omits the gadolinium contrast sequence, is a shorter and cheaper alternative offering time-saving capacity gains for health systems globally.
View Article and Find Full Text PDFPredictors of change in sleep disturbance in Canadian long-term care facilities: a longitudinal analysis based on interRAI assessments.
Eur Geriatr Med
September 2025
School of Public Health Sciences, University of Waterloo, Waterloo, Canada.
Purpose: Sleep disturbance is prevalent in long-term care facilities (LTCFs), yet there is limited understanding of individual factors predicting changes in sleep within these populations. Our objective was to determine predictors of sleep disturbance in LTCFs and investigate variation in prevalence across facilities in two Canadian provinces-New Brunswick and Saskatchewan.
Method: This retrospective longitudinal cohort study used interRAI comprehensive health assessment data from 2016 to 2021, encompassing 21,394 older adults aged ≥ 65 years across 228 LTCFs.