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Antimicrobial resistance (AMR) poses a significant threat to global public health, disproportionately affecting low- and middle-income countries (LMICs). While excessive antibiotic use is often discussed, the issue of access to antibiotics demands attention. This viewpoint explores the multidimensional nature of the issue of access to antibiotics. We have examined the issue through the lens of social, economic, healthcare structures, manufacturing and supply chain, policy and practices. Inter-relatedness of these issues has also been explored. The review further discusses potential solutions involving but not limited to increased awareness, improvement in healthcare infrastructure, models for sustained manufacturing and supply chains. Additionally, enhancing antimicrobial stewardship at hospital and community levels, empowering healthcare professionals, and emphasizing infection prevention are crucial. Global initiatives that aim to address access challenges, emphasizing collaboration and innovation are important to foster for a sustained response to the issue of antibiotic access.
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http://dx.doi.org/10.1007/s40290-024-00538-7 | DOI Listing |
Mol Biol Rep
September 2025
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran.
Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. The tumor microenvironment (TME), particularly the interactions between endothelial cells and cancer-associated fibroblasts (CAFs), plays a pivotal role in promoting tumor growth, angiogenesis, oxidative stress, and therapy resistance. The HUVEC-fibroblast co-culture model closely mimics stromal-endothelial interactions observed in CRC, enabling mechanistic insights not achievable in monocultures.
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August 2025
Medicine, Hadassah-Hebrew University Medical Center, Mount Scopus Campus and the Hebrew University-Hadassah Medical School, Jerusalem, ISR.
Adults with short bowel syndrome (SBS), malabsorption, and malnutrition often require long-term parenteral nutrition (PN), typically as total PN (TPN). These patients are susceptible to bloodstream infections and sepsis. We present a case of a 63-year-old male patient who developed SBS following an acute mesenteric event.
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August 2025
Internal Medicine, Centro Médico Nacional Siglo XXI, Mexico City, MEX.
Acute generalized exanthematous pustulosis (AGEP) is a rare, potentially severe cutaneous adverse reaction characterized by the rapid onset of numerous small, sterile pustules on edematous erythema, commonly accompanied by systemic symptoms such as high-grade fever and neutrophilic leukocytosis. AGEP is most frequently triggered by medications, especially antibiotics, though infections and other exposures can also be causative. We report the case of a previously healthy 27-year-old male patient who developed a febrile pustular eruption with systemic involvement.
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August 2025
Department of Orthopaedics, Asklipieio Voulas General Hospital, Athens, GRC.
Postoperative infections following orthopedic fixation can lead to devastating consequences, particularly in patients with comorbidities such as diabetes mellitus. We present a rare case of a 61-year-old female patient with a patella fracture treated with tension band wiring who developed a severe polymicrobial infection resulting in complete destruction of the patellar tendon. Multiple debridements, removal of implants, and prolonged targeted antibiotic therapy were necessary.
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August 2025
Pharmacology, Government Medical College, Patiala, IND.
Introduction The global rise in antimicrobial resistance (AMR) poses a serious public health threat, reducing the effectiveness of commonly used antibiotics against prevalent bacterial infections. The mushrooming of Indian e-pharmacies, especially during and after the COVID-19 pandemic, has improved public access to medicines, including antibiotics. However, the ease of availability, combined with an ambiguous regulatory framework governing e-pharmacies, may inadvertently encourage the irrational use of antibiotics.
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