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Autonomous driving presents unique challenges, particularly in transferring agents trained in simulation to real-world environments due to the discrepancies between the two. To address this issue, here we propose a robust Deep Reinforcement Learning (DRL) framework that incorporates platform-dependent perception modules to extract task-relevant information, enabling the training of a lane-following and overtaking agent in simulation. This framework facilitates the efficient transfer of the DRL agent to new simulated environments and the real world with minimal adjustments. We assess the performance of the agent across various driving scenarios in both simulation and the real world, comparing it to human drivers and a proportional-integral-derivative (PID) baseline in simulation. Additionally, we contrast it with other DRL baselines to clarify the rationale behind choosing this framework. Our proposed approach helps bridge the gaps between different platforms and the Simulation to Reality (Sim2Real) gap, allowing the trained agent to perform consistently in both simulation and real-world scenarios, effectively driving the vehicle.
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http://dx.doi.org/10.1038/s44172-024-00292-3 | DOI Listing |
BMJ Lead
September 2025
Green Templeton College, University of Oxford, Oxford, UK.
Background: In 2021, Dr Kalra embraced an opportunity for a leadership role at a start-up healthcare organisation in India. This gave him an opportunity to adapt his National Health Service (NHS) leadership experience to the evolving Indian private healthcare landscape. This paper shares his lived experience as a National Medical Director and delves into the experiences and leadership insights he acquired during this.
View Article and Find Full Text PDFWomen Birth
September 2025
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Department of Nursing, Mid Sweden University, Sundsvall, Sweden.
Background: Few parents experience stillbirth in Sweden, and their perspectives on the grieving process remain largely unknown.
Objective: To explore parents' perspectives, memories, reflections and insights in the grieving and recovery process six months after stillbirth.
Methods: A mixed-method study involving nine in-depth interviews and responses to eleven quantitative statements.
Sci Adv
September 2025
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson's disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic stimulation in mice, we hypothesized that STN-DBS can mimic dopaminergic reinforcement of ongoing movement kinematics during stimulation. To investigate this hypothesis, we delivered DBS bursts during particularly fast and slow movements in 24 patients with PD.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
This study aims to optimize the dynamic administration regimen of prophylactic enoxaparin in critically ill patients to reduce the risk of VTE, major bleeding, and 30-day all-cause mortality. We developed and internally and externally validated an artificial intelligence (AI) policy utilizing Double dueling deep Q network, using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database (training and internal test set) and the eICU Collaborative Research Database (eICU-CRD, external test set). We compared the performance among the AI policy, the clinician's policy, the weight-tiered policy, and the fixed 40- mg-once-daily (QD) policy.
View Article and Find Full Text PDFPLoS One
September 2025
College of Business Administration, Northern Border University (NBU), Arar, Kingdom of Saudi Arabia.
The increasing dependence on cloud computing as a cornerstone of modern technological infrastructures has introduced significant challenges in resource management. Traditional load-balancing techniques often prove inadequate in addressing cloud environments' dynamic and complex nature, resulting in suboptimal resource utilization and heightened operational costs. This paper presents a novel smart load-balancing strategy incorporating advanced techniques to mitigate these limitations.
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