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On September 28, 2023, a kitten aged approximately 6 weeks found in Omaha, Nebraska, had test results positive for rabies at the Nebraska Veterinary Diagnostic Center (NVDC) after dying with neurologic signs and having bitten and scratched its caretakers. Preliminary investigation identified 10 exposed persons for whom postexposure prophylaxis (PEP) was recommended. Subsequent variant-typing by NVDC yielded a presumptive positive result for the Eastern raccoon rabies virus variant (RRVV), which CDC confirmed on October 6.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486353 | PMC |
http://dx.doi.org/10.15585/mmwr.mm7341a4 | DOI Listing |
J Am Vet Med Assoc
July 2025
1Poxvirus and Rabies Branch, CDC, Atlanta, GA.
Objective: Describe the epidemiologic landscape of rabies and rabies testing in the US during 2023 and provide an overview of rabies in Canada and Mexico.
Methods: The US National Rabies Surveillance System collects monthly animal rabies testing data from 54 reporting jurisdictions. Data reported in 2023 were analyzed geographically and temporally to explore trends in animal rabies cases by rabies virus variant.
PLoS Negl Trop Dis
July 2025
USDA, APHIS, Wildlife Services, National Rabies Management Program, Concord, New Hampshire, United States of America.
Roadkill specimens are an important source of samples for enhanced rabies surveillance (ERS) in areas where other methods of sample collection may not be practical. However, the physical condition of roadkill specimens is unpredictable and, in many circumstances, unsatisfactory for rabies diagnostic testing by antigen detection methods. The high sensitivity of real-time reverse transcriptase PCR (RT-PCR) holds promise for rabies diagnostic testing of poor-quality samples.
View Article and Find Full Text PDFMicrobiol Spectr
August 2025
Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Rabies is a fatal zoonotic disease caused by the rabies virus (RABV), primarily affecting the central nervous system of mammals. Understanding the epidemiology of animal rabies is critical for developing effective prevention and control strategies. This study aimed to analyze animal rabies cases received at a veterinary diagnostic laboratory in Georgia, USA, over 5 years (2019-2023), focusing on the most commonly infected species, seasonality trends, and geographical distributions.
View Article and Find Full Text PDFSci Rep
June 2025
Poxvirus and Rabies Branch, United States Centers for Disease Control and Prevention, Atlanta, GA, USA.
Rabies virus (RABV) host-shift events (HSEs) are thought to be promoted by viral genomic and ecological factors, but the relative balance of the two is unclear. Using a dataset of 19,170 species pairs that were known or not known to be linked by an HSE, we developed a logistic regression model to explore how biological and ecological characteristics of cross-species infections and their associated RABV variant (RVV) influence HSE risk. The model incorporates relatedness, body temperature, litter size, adult weight, and the broad lineage (bat or canine) of the RABV variant maintained by the reservoir species.
View Article and Find Full Text PDFEvol Appl
May 2025
US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center Fort Collins Colorado USA.
Wide-ranging, generalist species provide both interesting and challenging opportunities for research questions focused on population structure. Their continuous distributions and ability to occupy diverse habitat types can obscure genetic signals of ancestry and geographic clustering. However, spatially informed population genetic approaches are notable for high-resolution identification of geographic clusters that often elude more classical clustering models.
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