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The increase in elderly populations worldwide highlights the urgency of addressing age-related problems through effective nutritional management to enhance the well-being of the elderly and for the prevention and treatment of various diseases. The trend towards an increasing elderly population brings with it an increase in conditions such as sarcopenia, osteosarcopenia and frailty, emphasising the importance of regular checks for malnutrition in the elderly and the implementation of personalised nutritional therapies. The importance of nutrition in addressing geriatric syndromes such as frailty, sarcopenia, osteosarcopenia, obesity and metabolic syndrome is highlighted. Dysphagia, frequent in the elderly, requires special attention to prevent malnutrition and complications. It is essential to maintain muscle mass and bone health in old age. In this review we investigate the fundamental role of nutrition in geriatrics, focusing on promoting healthy ageing and managing problems such as malnutrition and overeating. The importance of protein intake and healthy dietary patterns such as the Mediterranean diet are then discussed. Finally, the challenges of personalised nutritional care, including the need for artificial nutrition or oral supplements, to improve quality of life and health care in an ageing society are addressed.
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http://dx.doi.org/10.1038/s41430-024-01513-w | DOI Listing |
J Endocrinol
September 2025
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming 650500, China.
Osteosarcopenia (OS) is a syndrome defined by the concurrent presence of sarcopenia and osteoporosis in the elderly population, which markedly elevates the risk of falls, fractures, and mortality. Recent studies demonstrate that disruption of muscle-bone biochemical crosstalk emerges as a key driver of OS pathogenesis, and that targeting pivotal mediators and pathways can concurrently restore musculoskeletal homeostasis. However, the precise molecular mechanisms and targeted therapeutic strategies remain inadequately explored.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Osteosarcopenia is a widespread geriatric condition resulting from the coexistence of osteoporosis and sarcopenia, where the connection between bone and muscle is, in part, driven by bone-muscle crosstalk. Given the close, reciprocal influence of muscle on nerve, and vice versa, it is not surprising that there are corresponding aging changes in the biochemistry and morphology of the neuromuscular junction (NMJ). Indeed, degeneration of motor neurons and progressive disruption of the neuromuscular connectivity were observed in old age.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Department of Animal Physiology, University of Life Sciences in Lublin, 20-950 Lublin, Poland.
Osteosarcopenia, characterized by concurrent bone loss and muscle wasting, significantly impacts mobility and quality of life. While age-related primary osteosarcopenia is well-studied, secondary osteosarcopenia (SOS) caused by chronic diseases remains poorly understood, particularly in young individuals. The present study aimed to comprehensively characterize musculoskeletal alterations associated with SOS using a juvenile porcine model of cerulein-induced chronic pancreatitis.
View Article and Find Full Text PDFNorth Clin Istanb
June 2025
Department of Internal Medicine, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkiye.
Objective: There is limited knowledge regarding the clinical, biochemical, and functional characteristics of patients with osteosarcopenia. The present study aims to explore the presence of osteosarcopenia in patients aged 65 years and over who have a history of falls and hip fractures.
Methods: Seventy-six participants (77.
Exp Gerontol
October 2025
Department of Rehabilitation Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea; Department of Biomedical Institute, Chungnam National University, Daejeon, Republic of Korea. Electronic address:
Objective: We evaluated the efficacy of a 6-month progressive resistance exercise in postmenopausal women with osteosarcopenia.
Study Design: Thirty-four community-dwelling postmenopausal women with osteosarcopenia were randomly assigned to either a resistance exercise group (RE; n = 17) or a home exercise group (HE; n = 17). Both groups received home exercise brochures and nutritional supplementation.