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Article Abstract
Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cross-clade protective HPAI H5 vaccines are urgently needed. Here, we demonstrate the applicability of a lipid nanoparticle-based mRNA vaccine modality to induce cross-protective immunity against lethal HPAI virus infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473758 | PMC |
| http://dx.doi.org/10.1038/s41541-024-00988-9 | DOI Listing |
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