98%
921
2 minutes
20
Solid pseudopapillary neoplasms (SPNs) are uncommon pancreatic tumors that primarily affect young females. We report a case of a 24-year-old female diagnosed with SPN and liver metastasis during a routine examination. Imaging revealed an 8-cm pancreatic mass with multiple liver metastases. Histopathology confirmed SPN. Subsequent next-generation sequencing revealed a mutation. The patient underwent a total pancreatectomy with splenectomy, right hemihepatectomy, and intraoperative radiofrequency ablation. Two years after the surgery, she remained complication-free. She is under regular surveillance. This case underscores the importance of early detection and comprehensive management of SPN.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830896 | PMC |
http://dx.doi.org/10.14701/ahbps.24-147 | DOI Listing |
Background: Oncocytic differentiation in pancreatic neoplasms is uncommon but can be seen in a wide range of neoplasms which range from borderline to highly aggressive behavior. Certain tumors, such as Oncocytic Intraductal Papillary Neoplasm (IOPN) of the pancreas are oncocytic by default but many, such as neuroendocrine tumors (PanNET), can be oncocytic in a rare subset, often with clinical significance (like aggressive behavior). As such, the differential diagnosis can be broad and expertise is critical in teasing out the true diagnosis to guide treatment.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of General Surgery, Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Cang Zhou, China.
Rationale: Franz tumor, which has been classified as solid pseudopapillary neoplasm (SPN) of the pancreas, is a rare tumor with low malignant potential that occurs mainly in young women. Its clinical manifestations are atypical or asymptomatic, diagnosis is often incidental or detected by imaging for other reasons, and little is known about their optimal treatment. This analysis aimed to increase knowledge about the occurrence and treatment strategies of SPN.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Pathology, The First Hospital of Changsha, Changsha, Hunan Province, China.
Rationale: Solid pseudopapillary neoplasm of the pancreas, first classified as a malignant epithelial tumor of the pancreas in 2019, is rare and usually occurs in young women, with a high incidence at approximately 30 years of age. Herein, we present a case of solid pseudopapillary neoplasm of the pancreas with elevated β-human chorionic gonadotropin (HCG) levels, which, to our knowledge, has not been reported in the literature.
Patient Concerns: A 35-year-old woman of childbearing age presented with a chief complaint of vaginal bleeding and was admitted to our hospital.
Radiol Case Rep
November 2025
Hepato-Gastroenterology Department, Mohammed VI University Hospital, Oujda, Morocco.
Solid pseudopapillary tumor of the pancreas (SPTP) is a rare exocrine pancreatic neoplasm accounting for less than 2% of cases, predominantly affecting young women. This article presents 4 cases of SPTP occurring in women aged 19-33 years, all with tumors located in the head of the pancreas and varying in size from 5 cm to 11 cm. Three patients presented with abdominal pain, and one was asymptomatic with incidental discovery during pregnancy.
View Article and Find Full Text PDFCureus
August 2025
Department of Gastroenterology, Sapporo City General Hospital, Sapporo, JPN.
Pancreatic schwannomas are extremely rare benign tumors originating from Schwann cells of peripheral nerves, often mimicking more common pancreatic tumors, such as neuroendocrine neoplasms or solid pseudopapillary neoplasms, making preoperative diagnosis challenging. We describe a 65-year-old asymptomatic man referred for evaluation of an incidental pancreatic body mass detected by ultrasound. Laboratory findings, including liver enzymes and tumor markers (CA19-9 and CEA), were normal.
View Article and Find Full Text PDF