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Calcifying pseudoneoplasm of the neuraxis (CAPNON) is an uncommon entity and a rare cause of third cranial nerve palsy. We review the case of a 17-year-old male with a 9-month history of progressive left third cranial nerve palsy. Cerebral magnetic resonance image showed a left clinoidal lesion with low signal intensity in T2 and T1 sequences with signs of calcification in the computed tomography and without vascular lesion in AngioMRI. A left pterional approach was performed with posterior clinoidectomy and total resection of the lesion. Calcifying pseudoneoplasm of the neuraxis is an infrequent pathology that presents in the skull base and spine that requires surgical treatment in the presence of compressive phenomena and differential diagnosis as meningioma, chordoma, and metastasis should be considered.
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http://dx.doi.org/10.1093/jscr/rjae507 | DOI Listing |
Asian J Neurosurg
September 2025
Department of Neurosurgery, Asahi University Hospital, Gifu, Japan.
Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare non-neoplastic calcified lesions that can occur throughout the entire neuraxis. Cranial nerves may be involved in skull base lesions. Surgical resection usually has a good prognosis, with only a few cases of recurrence reported in the relevant literature.
View Article and Find Full Text PDFJ Neurosurg Case Lessons
May 2025
Northeast Louisiana Radiation Oncology, Monroe, Louisiana.
Background: Trauma-associated glioblastoma has been previously described, albeit without molecular characterization.
Observations: The authors show the integrated clinical/pathologic/molecular analysis of a glioblastoma developing 43 years after head trauma sustained by a United States veteran. An epileptogenic benign lesion developed at the trauma site, followed 34 years later by a calcified lesion diagnosed as calcifying pseudoneoplasm of the neuraxis (CAPNON) that recurred 9 years later as glioblastoma with heterotopic/metaplastic ossification.
J Clin Neurosci
February 2025
Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore, India. Electronic address:
J Surg Case Rep
October 2024
Neurocirugía, Fundación Valle del Lili, Cali 760026, Colombia.
Calcifying pseudoneoplasm of the neuraxis (CAPNON) is an uncommon entity and a rare cause of third cranial nerve palsy. We review the case of a 17-year-old male with a 9-month history of progressive left third cranial nerve palsy. Cerebral magnetic resonance image showed a left clinoidal lesion with low signal intensity in T2 and T1 sequences with signs of calcification in the computed tomography and without vascular lesion in AngioMRI.
View Article and Find Full Text PDFBalkan Med J
September 2024
Department of Radiology, Division of Neuroradiology, University of Iowa Hospitals and Clinics, Iowa City-IA, USA