Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study.

Introduction: Risk factors for serrated polyps (SPs) are not well understood.

Methods: Multivariable analyses of data from a multicenter colonoscopy-based study estimated odds ratios for having either a sessile serrated lesion or traditional serrated adenoma according to participant characteristics.

Results: Six thousand seventy-eighty participants were included in the analyses (565 with either a sessile serrated lesion or traditional serrated adenoma). White race was associated with a higher risk of SPs compared with Black race (adjusted odds ratio 4.64, 95% confidence interval 1.89-11.41). Obesity and current smoking were also associated with a higher risk of SPs.

Discussion: White race, smoking, and obesity are risk factors for precancerous SPs.