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Purpose: This pilot study investigated delivering enhanced milieu teaching tailored for children with Down Syndrome (EMT-DS) through hybrid telepractice.
Method: In this multiple-baseline design across behaviors study, a speech-language pathologist (SLP) taught EMT-DS to three caregivers and their children with DS (22-40 months) using a hybrid service delivery model. Sessions were conducted in person and via telepractice. The SLP taught caregivers EMT-DS, emphasizing the use of (a) four target EMT strategies: matched turns, expansions, time delays, and milieu teaching episodes; (b) augmentative and alternative communication (AAC; manual signs, speech-generating device); and (c) aided AAC modeling. The SLP provided caregiver instruction following the teach-model-coach-review approach. Caregiver outcomes were the accuracy (primary) and frequency (secondary) of EMT strategy use. Child outcomes were exploratory and included the rate of symbolic communication acts, weighted number of communication acts, and number of different words (NDW).
Results: There was a functional relation between the intervention and the accuracy and frequency of EMT strategy use for all three caregivers. All caregivers showed an increase in the accuracy for all four target strategies. Caregivers also increased the frequency of the three EMT strategies: expansions, time delays, and milieu teaching episodes. There were no changes in the frequency of matched turns. Caregiver use of EMT strategies maintained for 6 weeks post-intervention. After caregivers learned EMT strategies, gradual increases in the rate of symbolic communication acts and NDW occurred for all three children.
Conclusion: Results demonstrate the preliminary efficacy of using a hybrid service delivery model to teach caregivers EMT-DS.
Supplemental Material: https://doi.org/10.23641/asha.27115252.
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http://dx.doi.org/10.1044/2024_AJSLP-23-00454 | DOI Listing |
Cardiol Young
August 2025
Pediatric & Congenital Heart Surgery, Fortis Escorts Heart Institute, Okhla Road, New Delhi, New Delhi, 110025, India.
The oldest civilisation on the face of the Earth can be traced to India, home to the largest democracy of our times. Fast forward five millenia, a young nation at 78 places the aortic cross clamp most of others on a per diem basis. Somewhere in between, Donald Nixon Ross, who has been interred in this great Hall of Fame [1] opined that "it is rare to know of surgeons who can perform an operation better and often, seamless than its namesake, and among the few there are, Sampath Kumar is one".
View Article and Find Full Text PDFAcad Pediatr
August 2025
University of Ottawa, Ottawa, Ontario, Canada.
Background: Pediatricians require primary palliative care (PC) skills - communication, pain and symptom management, and psychosocial support - to provide care that mitigates suffering for children with serious illnesses. Residents may not develop skills adequately, and little is known about how they learn those that they do have.
Objective: To explore effective primary PC learning in Canadian pediatrics residency programs.
Front Cell Dev Biol
August 2025
School of Physical Education, Zaozhuang University, Zaozhuang, China.
Skeletal muscle development and adaptation are governed by complex regulatory networks that coordinate gene expression, signaling pathways, and intercellular communication. Among the emerging key regulators are microRNAs (miRNAs) and exosomal microRNAs, which function as critical modulators of skeletal muscle growth, differentiation, regeneration, and metabolic adaptation. The review explores the acknowledged contributions of miRNAs, both intracellular and those encapsulated within exosomes, to the regulation of skeletal muscle physiology.
View Article and Find Full Text PDFBiointerphases
July 2025
Department of Mechanical Engineering, Indian Institute of Science, Bangalore 560012, India.
Mechanical properties of the extracellular matrix (ECM) modulate cell-substrate interactions and influence cellular behaviors such as contractility, migration, and proliferation. Although the effects of substrate stiffness on mechanobiology have been well studied, the role of ECM viscoelasticity in fibrotic progression remains less understood. To examine how viscoelasticity affects the biophysical properties and regulates signaling of human mammary fibroblasts, we engineered elastic (E) and viscoelastic (VE) polyacrylamide hydrogels with comparable storage moduli (∼14.
View Article and Find Full Text PDFInorg Chem
August 2025
School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram (IISER-TVM), Thiruvananthapuram 695551, India.
Although nitrite-to-nitric oxide (NO) transformation from the interactions between a thiol and nitrite at classical transition-metal sites is well known in the context of understanding the enzymatic reduction of nitrite, insights into the nonenzymatic routes affording NO gas and factors affecting such pathways are poorly understood. This study illustrates a biologically relevant crosstalk among nitrite, thiol, and organic dichalcogenides with -SeS- and -SeSe- moieties, resulting in a facile protonation of nitrite to provide transient nitrous acid (HNO). The overall transformation of nitrite to NO and nitrate is proposed to occur through the disproportionation of metastable HNO.
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