Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

According to the current definitions of recurrence of non-muscle-invasive bladder cancer after bacillus Calmette-Guérin (BCG), patients in the BCG-exposed and late relapse categories might benefit from further instillations. Patients with BCG-unresponsive disease could be included in clinical trials, but otherwise radical cystectomy is the preferred treatment. BCG-intolerant disease still represents an area of debate, with limited evidence regarding the best treatment for these patients.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euo.2024.09.010DOI Listing

Publication Analysis

Top Keywords

bacillus calmette-guérin
8
lights shadows
4
shadows bacillus
4
calmette-guérin bcg-exposed
4
bcg-exposed bcg-unresponsive
4
bcg-unresponsive definitions
4
definitions practical
4
practical overview
4
overview current
4
current definitions
4

Similar Publications

Bacillus drives functional states in synthetic plant root bacterial communities.

Genome Biol

September 2025

Department of Biology, Plant-Microbe Interactions, Science for Life, Utrecht University, Utrecht, 3584CH, The Netherlands.

Background: Plant roots release root exudates to attract microbes that form root communities, which in turn promote plant health and growth. Root community assembly arises from millions of interactions between microbes and the plant, leading to robust and stable microbial networks. To manage the complexity of natural root microbiomes for research purposes, scientists have developed reductionist approaches using synthetic microbial inocula (SynComs).

View Article and Find Full Text PDF

This study investigated the inhibitory effect of sucrose on the autolysis of recombinant Bacillus subtilis WB600 during keratinase production and elucidated its mechanism. Growth curves, cell morphology observations, cell wall integrity detection, and transcriptome analysis revealed that 2 % sucrose significantly increased cell biomass and delayed autolysis. Keratinase activity reached 5670.

View Article and Find Full Text PDF

Objectives: Antibiotic resistance towards penicillin has been attempted to counter by chemically modifying ampicillin through the conjugation with silver nanoparticles (AgNPs). The current study optimizes the conditions for synthesizing and characterizing AgNP-ampicillin to quantify the conjugation extent, evaluate the antibacterial efficacy, and explore the underlying antibacterial mechanisms.

Materials And Methods: AgNPs were synthesized from silver nitrate by chemical reduction method, silica-coated with tetraethyl orthosilicate (TEOS) and amine functionalized by (3-aminopropyl) triethoxysilane (APTES), which was then conjugated with ampicillin via the carbodiimide chemistry.

View Article and Find Full Text PDF

The biting midges, Culicoides peregrinus Kieffer and Culicoides oxystoma Kieffer (Diptera: Ceratopogonidae) are the most significant vector species of bluetongue virus (BTV) in the Oriental region, including India. Rearing of these vector species was cumbersome; previous researchers supplemented the rearing substrates primarily with cattle dung (the habitat), yeast and nutrient broth. Other investigations reiterated that an enriched milieu of live bacteria is required for the oviposition and developmental progression of the immatures as they failed to develop in sterile medium.

View Article and Find Full Text PDF