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The jet stream is an important dynamic driver of climate variability in the Northern Hemisphere mid-latitudes. Modern variability in the position of summer jet stream latitude in the North Atlantic-European sector (EU JSL) promotes dipole patterns in air pressure, temperature, precipitation and drought between northwestern and southeastern Europe. EU JSL variability and its impacts on regional climatic extremes and societal events are poorly understood, particularly before anthropogenic warming. Based on three temperature-sensitive European tree-ring records, we develop a reconstruction of interannual summer EU JSL variability over the period 1300-2004 CE (R = 38.5%) and compare it to independent historical documented climatic and societal records, such as grape harvest, grain prices, plagues and human mortality. Here we show contrasting summer climate extremes associated with EU JSL variability back to 1300 CE as well as biophysical, economic and human demographic impacts, including wildfires and epidemics. In light of projections for altered jet stream behaviour and intensified climate extremes, our findings underscore the importance of considering EU JSL variability when evaluating amplified future climate risk.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485261 | PMC |
http://dx.doi.org/10.1038/s41586-024-07985-x | DOI Listing |
ACS Eng Au
August 2025
Department of Chemical and Biomolecular Engineering, Tandon School of Engineering, New York University, Brooklyn 11201, United States.
Polymeric microparticles (MPs) are valuable drug delivery vehicles for extended-release applications, but current manufacturing techniques present significant challenges in balancing size control with scalability. Industrial synthesis processes provide high throughput but limited precision, while laboratory-scale technologies offer precise control but poor scalability. This study explores Sequential NanoPrecipitation (SNaP), a two-step controlled precipitation process for polymeric microparticle production, to bridge the gap between laboratory precision and industrial scalability.
View Article and Find Full Text PDFTransl Vis Sci Technol
August 2025
School of Engineering, Newcastle University, Newcastle upon Tyne, UK.
Purpose: The purpose of this study was to investigate the field of fluidic effect (FOE) at the vitrectomy port in a range of artificial vitreous solutions (AVS) with varying rheological characteristics to add insight into the effects surgeons observe during vitrectomy and how they change with a variety of console settings.
Methods: Laboratory-based investigation using in vitro testing was carried out at Newcastle University, United Kingdom. Testing was conducted using an Eva Nexus Vitrectomy system (D.
Data Brief
October 2025
Mechanical Engineering Department, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, 15213, PA, USA.
This dataset reports the characterization and data processing methodology of 45 individual AISI 316L single melt tracks, fabricated by powder blown laser beam directed energy deposition (DED-LB) metal additive manufacturing. The melt tracks were deposited across a parametric combination of process parameters: powder size distributions, carrier gas flow rates, and laser spot diameter-laser power sets. The measured melt track properties include the average melt track width, height, cross-sectional area, and the powder catchment efficiency.
View Article and Find Full Text PDFNat Commun
August 2025
Department of Naval Architecture, Ocean & Marine Engineering, University of Strathclyde, Glasgow, UK.
Liquid jet formations on water surfaces serve as a cornerstone in diverse scientific disciplines, underpinning processes in climatology, environmental science, and human health issues. Traditional models predominantly focus on pristine conditions, an idealisation that overlooks common environmental irregularities such as the presence of particulate matter on water surfaces. To address this shortfall, our research examines the dynamic interactions between surface particulate matter and cavitation bubbles using floating spheres and spark bubbles.
View Article and Find Full Text PDFInt J Pharm
October 2025
Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, NSW 2006, Australia. Electronic address:
Liposome-encapsulated bacteriophages offer promising potential for targeted antimicrobial therapy against multidrug-resistant infections, by enhancing phage stability and delivery. Current encapsulation methods face challenges due to low efficiency (≤50 %), phage inactivation, and limited scalability for industrial production. To overcome these challenges, this study presents an electrostatically driven encapsulation method to produce phage liposomal formulations using cationic lipids (DOTAP) in various scalable micromixing systems (AXF™mini, confined impinging jet (CIJ), microfluidic chip).
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