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http://dx.doi.org/10.1021/acsami.4c15976 | DOI Listing |
Int Ophthalmol
September 2025
Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technolog
Purpose: To analyze macular microvascular networks and investigate correlations between visual acuity and quantitative parameters in patients with Leber's hereditary optic neuropathy (LHON) using optical coherence tomography angiography (OCTA).
Methods: An observational, cross-sectional study was conducted, including 25 eyes from 25 genetically confirmed chronic LHON patients and 25 eyes from 25 age-matched healthy controls. Images were obtained using a spectral domain OCTA system.
Nat Immunol
September 2025
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Gene Ther
September 2025
ENDomics Lab, Department of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nat Commun
September 2025
Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan.
Since Hans Driesch's pioneering work in 1891, it has been known that animal embryos can develop into complete individuals even when divided. However, the developmental processes and molecular mechanisms enabling this self-organization remain poorly understood. In this study, we revisit Driesch's experiments by examining the development of isolated 2-cell stage blastomeres in the sea urchin, Hemicentrotus pulcherrimus.
View Article and Find Full Text PDFJ Physiol
September 2025
Department of Physiology, Anatomy & Genetics, University of Oxford and Daegu-Gyeongbuk Institute of Science and Technology, South Korea.
The cardiac pacemaker activity is formed from multiple interlocking physiological networks, any one of which can generate rhythm. The interlocking is reciprocal so that they automatically replace each other. In such interlocking control systems, the association scores for individual components are necessarily low, even though causation, measured by the electric current carried by the relevant ion channels, is large.
View Article and Find Full Text PDF