Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Purpose: To describe the features of peripheral retinal degenerations using an Ultra-Widefield (UWF) Swept Source Optical Coherence Tomography (SS-OCT).

Method: In this cross-sectional study done at a tertiary eye care centre in Northern India, peripheral retinal degenerations such as lattices, snail track lesion, paving stone, White With-Out Pressure(WWOP), micro-cystoid lesions, retinoschisis and other suspicious lesions were identified with clinical examination. Following clinical examination, these eyes with peripheral retinal degenerations underwent UWF OCT.

Results: 100 eyes with 14 peripheral lesions like lattices (31%), snail track lesions (10.4%), peripheral retinoschisis (7.5%), non-specific pigmented doubtful lesions (13.2%), WWOP (7.5%), paving stone (6.6%), peripheral retinal detachment (3.8%) along with CHRPE, micro-cystoid lesions and dark without pressure areas were identified. All the lesions could be imaged with the help of UWF-OCT. It significantly helped in improving diagnostic capability with early identification of specific structural features such as vitreoretinal attachment and traction, full-thickness hole or tear, and sub-retinal fluid which were not so evident on indirect ophthalmoscopy.

Conclusion: UWF-OCT deepens our understanding of the structure of the retina and its associated peripheral pathologies, allowing early recognition of vision-threatening lesions that may influence clinical management.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-024-06593-9DOI Listing

Publication Analysis

Top Keywords

peripheral retinal
20
retinal degenerations
16
degenerations ultra-widefield
8
swept source
8
source optical
8
optical coherence
8
coherence tomography
8
snail track
8
paving stone
8
lesions
8

Similar Publications

Bilateral multiple retinal pigment epithelial detachments.

Doc Ophthalmol

September 2025

Department of Ophthalmology, Saitama Medical University Faculty of Medicine, 38 Moro-Hongo Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Purpose: To report a rare case of bilateral idiopathic multifocal retinal pigment epithelial detachments (imfPEDs) and to describe the long-term morphological and functional changes observed over a 16-year follow-up period.

Methods: A 49-year-old woman was diagnosed with imfPEDs based on multimodal imaging, including optical coherence tomography (OCT), fluorescein angiography (FA), and fundus photography. Full-field electroretinograms (ffERGs) and multifocal ERGs (mfERGs) were recorded to assess retinal function.

View Article and Find Full Text PDF

Strategies to stimulate the regeneration of neurons in the adult central nervous system can offer universal solutions for neurodegenerative diseases. Taking lessons from naturally regenerating species, such as the zebrafish, we have previously shown that vector-mediated expression of proneural transcription factors can stimulate neurogenesis from the resident Müller glia (MG) population in the adult mouse retina, both and . To bring this closer to translation, we now show that vector-mediated expression of the proneural transcription factor ASCL1 can reprogram adult macaque MG into functional neurons.

View Article and Find Full Text PDF

The corneal lens is an apical extracellular matrix (aECM) structure with a biconvex shape that enables it to focus light. Chitin, a polymer of N-acetylglucosamine, is a major component of insect corneal lenses . Delayed chitin deposition in mutants and altered levels of chitin processing enzymes in mutants correlate with changes in the shape of corneal lenses , prompting us to investigate the role of chitin in determining corneal lens shape.

View Article and Find Full Text PDF

Retinal hypoxia may contribute to the development of preretinal neovascularization in patients with retinopathy of prematurity (ROP). Ciliary bodies compensate oxygen delivery to the retina, and the levels of hypoxia may vary across the peripheral avascular area in ROP. In this study, we have investigated a direct method for imaging gradient levels of retinal hypoxia at the peripheral avascular retina using a model ROP.

View Article and Find Full Text PDF

Rare Case of Systemic Cryptococcal Lymphadenopathy in a Persian Cat.

Vet Med Sci

September 2025

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam Nation University, Gwangju, South Korea.

Background: Cryptococcosis is the most common systemic fungal infection in cats, typically presenting with respiratory or neurological signs. However, cases without these hallmark symptoms are rare and often misdiagnosed. This case is noteworthy for its atypical presentation, where a cat developed systemic cryptococcosis without the typical respiratory or neurological involvement, making it particularly challenging to diagnose.

View Article and Find Full Text PDF