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| http://dx.doi.org/10.1001/jamacardio.2024.2966 | DOI Listing |
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Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance.
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Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to which they seasonally adjust cardiac thermal performance and adrenergic control. We assessed the intrinsic and maximum heart rate (f and f) of anaesthetised fish through cholinergic blockade and either adrenergic blockade (f) or stimulation (f) during acute warming.
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Background: Cardiac resynchronization therapy (CRT) has been established as a key component in the management of patients with heart failure (HF) with reduced ejection fraction in addition to pharmacologic therapy. Several automatic algorithms have been developed to optimize the timing cycle settings in CRT, especially AV delay which was associated with improvement of the response to CRT. The present study aims to investigate whether the novel device-based SyncAV algorithm could elicit better synchrony and acute hemodynamic response.
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