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http://dx.doi.org/10.1053/j.jvca.2024.08.023 | DOI Listing |
bioRxiv
August 2025
Department of Pulmonary Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Zonula adherens junctions (zAJ) are spatially proximal to tight junctions (TJ), in a superstructure known as the apical junctional complex (AJC). A key component of the AJC is a circumferential ring of filamentous (F)-actin, but how actomyosin contractility drives AJC structure and epithelial barrier function is incompletely understood. Here, we show that a central mechanosensitive component of zAJ, α-catenin (α-cat), undergoes force-dependent phosphorylation in an unstructured linker region.
View Article and Find Full Text PDFBMC Pediatr
August 2025
Department of Pediatrics, Baoding Maternal and Child Health Hospital, Baoding, Hebei, China.
Background: Despite significant advancements in neonatal care, mid to late preterm infants (32-36 weeks' gestation) remain at high risk for recurrent respiratory tract infections (RRTIs). Current prevention strategies are limited by the absence of individualized risk assessment tools. This study aimed to identify critical perinatal risk factors and to develop a robust, clinically applicable prediction model for RRTI in this vulnerable population.
View Article and Find Full Text PDFSensors (Basel)
August 2025
School of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China.
The extensive deployment of quadrotors in complex environmental missions has revealed a critical challenge: degradation of trajectory tracking accuracy due to time-varying wind disturbances. Conventional model-based controllers struggle to adapt to nonlinear wind field dynamics, while data-driven approaches often suffer from catastrophic forgetting that compromises environmental adaptability. This paper proposes a reinforcement learning framework with continual adaptation capabilities to enhance robust tracking performance for quadrotors operating in dynamic wind fields.
View Article and Find Full Text PDFMaterials (Basel)
August 2025
Sichuan Highway Engineering Consulting and Supervision Co., Ltd., Chengdu 610000, China.
This study addresses the low reactivity and poor toughness of diabase tailings (DT), a high-silica industrial byproduct, which restricts their large-scale application in geopolymer binders. To overcome these limitations, a dual-regulation strategy integrating stepwise low-temperature thermal activation (100, 200, and 300 °C) with standard curing (20 ± 2 °C, 95% RH) was developed. This approach aimed to enhance mineral dissolution kinetics and facilitate the formation of a dense, interconnected gel network.
View Article and Find Full Text PDFJ Clin Med
August 2025
Department of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.
: Eccentric cycling exercise (ECC) offers a low-metabolic-demand approach to exercise, potentially making it valuable for patients with pulmonary vascular disease (PVD). The aim of this study was to investigate how quadriceps and frontal cortex oxygenation, assessed by near-infrared spectroscopy (NIRS), differs during ECC compared to concentric cycling exercise (CON) in patients with PVD and in healthy individuals. : This randomized controlled crossover trial involved patients with PVD, defined as either pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH), and healthy volunteers.
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