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http://dx.doi.org/10.1016/j.annonc.2024.08.2349 | DOI Listing |
Int J Colorectal Dis
September 2025
Proctology Department, Diaconesses Croix Saint-Simon Hospital Group, 125 Rue d'Avron, 75020, Paris, France.
Background And Aims: This study aimed to describe Crohn's disease perianal fistulizing lesions in patients undergoing surgery over 60 years to compare clinical presentation, management and outcomes with those observed in younger patients.
Methods: Between January 2012 and December 2022, all patients over 60 years old who underwent a first surgical intervention for anal fistula at two medical centers were included. For each patient included, two younger patients who underwent the same surgical procedure during the same period in the same centers were matched for comparison.
Surg Endosc
September 2025
Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Background: Current guidelines recommend that rectal neuroendocrine tumors (NETs) smaller than 10 mm can be treated by endoscopic resection, whereas tumors larger than 20 mm should be treated by surgical resection. However, the optimal treatment of 10-20 mm rectal NETs remains controversial. We aimed to evaluate the efficacy of endoscopic submucosal dissection (ESD) for 10-20 mm rectal NETs based on resection margin status.
View Article and Find Full Text PDFInt J Cancer
September 2025
Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
A subset of rectal cancer (RC), <5%, exhibits mismatch repair deficiency (dMMR); the remaining are classified as proficient (pMMR). Reported evidence on differences between dMMR and pMMR RC is limited. In this nationwide Dutch study, we compared patients with dMMR and pMMR stage II/III RC based on patient and tumor characteristics, treatment patterns, and associated outcomes.
View Article and Find Full Text PDFUrol Case Rep
September 2025
Pediatric Surgery Department "A", Children Hospital Bechir Hamza, Tunis, Tunisia.
We present a rare case of a full-term male neonate with a complex perineal anomaly featuring a mucosa-lined cleft extending from the penile base to the right gluteal fold, accompanied by penoscrotal transposition, hemiscrotal hypoplasia, and hypospadias. The lesion's anatomical and histological characteristics suggest antenatal rupture of a rectal duplication cyst. This report highlights the diagnostic challenges of exteriorized rectal duplications and underscores the importance of multistage reconstruction for optimal functional and cosmetic outcomes.
View Article and Find Full Text PDFIntroduction: Precise prediction of pathological complete response (pCR) following neoadjuvant chemoradiotherapy (nCRT) in rectal cancer may identify candidates for non-operative management. The optimal selection of diagnostic tools is therefore of major clinical importance.
Methods: Clinical, laboratory, endoscopic and radiological data of patients with rectal cancer treated with nCRT and surgery at an academic medical center from 2010 to 2020 were retrospectively collected.