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http://dx.doi.org/10.1001/jamanetworkopen.2024.33009 | DOI Listing |
Haematologica
September 2025
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD,.
Immunotherapies, including cell therapies, are effective anti-cancer agents. However, cellular product persistence can be limiting with short functional duration of activity contributing to disease relapse. A variety of manufacturing protocols are used to generate therapeutic engineered T-cells; these differ in techniques used for T-cell isolation, activation, genetic modification, and other methodology.
View Article and Find Full Text PDFStroke
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT (L.H.S.).
Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials.
View Article and Find Full Text PDFJ Paediatr Child Health
September 2025
Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Aim: To measure the prevalence of BF amongst Brazilian children aged 12-24 months, assess associated social determinants and evaluate the impact of maternal knowledge about its benefits.
Methods: A cross-sectional study was conducted between September and December 2024, using an online questionnaire completed by Brazilian mothers with children aged 12-24 months. Sociodemographic data were collected, including maternal and child age, education level, marital status, ethnicity, household income and employment status.
Chembiochem
September 2025
Department of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, 101 Roosevelt Avenue., Eau Claire, Wisconsin, 54701, USA.
The development of synthetically-useful biocatalysts requires characterizing the behavior of an enzyme under conditions amenable to preparative-scale reactions. Whole cells harboring the catalyst of interest are often used in such reactions, as protein purification is laborious and expensive. However, monitoring reaction rates when using whole cells is challenging, as cellular debris precludes the use of a continuous assay.
View Article and Find Full Text PDF