98%
921
2 minutes
20
Photochromic diarylethene has attracted broad research interest in optical applications owing to its excellent fatigue resistance and unique bistability. Photoswitchable fluorescent diarylethene become a powerful molecular tool for fluorescence imaging recently. Herein, the recent progress on photoswitchable fluorescent diarylethenes in bioimaging is reviewed. We summarize the structures and properties of diarylethene fluorescence probes and emphatically introduce their applications in bioimaging as well as super-resolution imaging. Additionally, we highlight the current challenges in practical applications and provide the prospects of the future development directions of photoswitchable fluorescent diarylethene in the field of bioimaging. This comprehensive review aims to stimulate further research into higher-performance photoswitchable fluorescent molecules and advance their progress in biological application.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1002/cbic.202400326 | DOI Listing |
Angew Chem Int Ed Engl
September 2025
Department of Chemistry, Dartmouth College, Hanover, NH, 03755, USA.
The fine-tuning of the (photo)physical properties of molecular photoswitches remains an active area of research, and recently, the incorporation of heterocycles into photoswitch scaffolds has emerged as an effective strategy in this vein. To assess the influence that heterocyclic rings have on hydrazone-based systems, we synthesized a series of photoswitches and examined the impact that heterocycles have on the switching efficiency. TD-DFT calculations and structure-property analyses revealed that heterocycles with basic nitrogen and secondary hydrogen-bonding sites (e.
View Article and Find Full Text PDFMed Res Rev
September 2025
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport, SLCs have emerged as crucial players in health and disease. Dysregulation of SLC function has been implicated in a spectrum of disorders, including metabolic diseases, cancer, and neurological afflictions.
View Article and Find Full Text PDFJ Fluoresc
September 2025
Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, South Ambazari Road, Nagpur, 440010, Maharashtra, India.
Logic operations at the molecular level are anticipated to play key role in data processing and storage in the future. However, most of these chemical systems rely on foreign chemical inputs. In contrast, opto-chemical logic devices are simpler to implement due to the ease of optical changes compared to pure chemical ones.
View Article and Find Full Text PDFChem Sci
August 2025
Department of Chemistry, Dartmouth College Hanover New Hampshire 03755 USA
Azo-BF complexes are visible and near-infrared (NIR) light-activated photoswitches showcasing versatility in applications ranging from energy storage to three-dimensional displays. While highly appealing as molecular switches, factors that affect their photophysical properties and solution-state reactivity still need to be teased out. In this paper, we present the synthesis and characterization of two azo-BF analogues (1 and 2), each modified with structurally distinct dimethylamine-substituted naphthalene moieties.
View Article and Find Full Text PDFChem Sci
August 2025
School of Chemistry, University of East Anglia Norwich NR4 7TJ UK
Reversibly switchable fluorescent proteins (rsFPs) are essential tools in super-resolution imaging. The mechanism operating in the widely applied negative switching rsFPs has been studied in detail. Much less attention has been paid to the positive switching rsFP variants, which offer the potential benefit of emissive states that do not photoswitch during measurement.
View Article and Find Full Text PDF