Synergistic effect of new pyrimidine derivative with oxacilin against methicillin-resistant .

This work aimed to synthesize a new pyrimidine with potential application against antimicrobial resistance. was synthesized through condensation reaction between and . The antimicrobial evaluation was carried out using the microdilution method in Mueller-Hinton Agar and predictions using different software. has moderate antibiotic activity and high capacity to efficiently modulate antibiotic resistance in . evaluations demonstrated that is probably an allosteric inhibitor of Protein Binding Penicilin 2a and modulates the action of oxacillin by decreasing the minimum inhibitory concentration by 64-times. demonstrate a good pharmacokinetic profile and toxicological. has great potential to go further in investigating its use against antimicrobial resistance.