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Article Abstract
In the past decade, ibrutinib has transformed the treatment landscape for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Two pivotal US Intergroups trials (E1912 and A041202) have established ibrutinib as the frontline treatment option for patients with treatment-naïve CLL in both young and fit, and old and frail populations. The cardiovascular side effect profile such as cardiac dysrhythmias, ischemic events and hypertension continues to be meticulously reported in all trials investigating ibrutinib and all other Bruton tyrosine kinase inhibitors for CLL/SLL. Herein, we utilized pooled data from two pivotal US Intergroup trials (A041202 and E1912) to report and evaluate ibrutinib associated pericardial events (including pericardial effusion, pericarditis, and tamponade).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11486548 | PMC |
| http://dx.doi.org/10.1111/bjh.19710 | DOI Listing |
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