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Walking is crucial for independence and quality of life. This study leverages wrist-worn sensor data from UK Biobank participants to establish normative daily-life walking data, stratified by age and sex, to provide benchmarks for research and clinical practice. The Watch Walk digital biomarkers were developed, validated, and applied to 92,022 participants aged 45-79 who wore a wrist sensor for at least three days. Normative data were collected for daily-life walking speed, step-time variability, step count, and 17 other gait and sleep biomarkers. Test-retest reliability was calculated, and associations with sex, age, self-reported walking pace, and mobility problems were examined. Population mean maximal and usual walking speeds were 1.49 and 1.15 m/s, respectively. The daily step count was 7749 steps, and step regularity was 65%. Women walked more regularly but slower than men. Walking speed, step count, longest walk duration, and step regularity decreased with age. Walking speed is associated with sex, age, self-reported pace, and mobility problems. Test-retest reliability was good to excellent (ICC ≥ 0.80). This study provides large-scale normative data and benchmarks for wrist-sensor-derived digital gait and sleep biomarkers from real-world data for future research and clinical applications.
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http://dx.doi.org/10.3390/s24165159 | DOI Listing |
BMC Neurol
September 2025
Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany.
Background: Parkinson's disease (PD) is characterized by motor symptoms altering gait domains such as slow walking speed, reduced step and stride length, and increased double support time. Gait disturbances occur in the early, mild to moderate, and advanced stages of the disease in both backward walking (BW) and forward walking (FW), but are more pronounced in BW. At this point, however, no information is available about BW performance and disease stages specified using the Hoehn and Yahr (H&Y) scale.
View Article and Find Full Text PDFPhysiother Theory Pract
September 2025
School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
Background: Knee osteoarthritis (OA) causes pain and diminishes quality of life. Backward walking exercise (BWE) has been shown to improve lower muscle strength and reduce knee adduction moment, making it a recommended intervention for knee OA rehabilitation. This study aims to evaluate the effectiveness of BWE combined with conventional rehabilitation programs on pain intensity and disability among individuals with knee OA.
View Article and Find Full Text PDFJ Biomech
August 2025
Lampe Joint Department of Biomedical Engineering, UNC Chapel Hill & NC State University, Chapel Hill, NC, USA. Electronic address:
Walking is essential for maintaining independence and quality of life, yet aging may impair the neuromuscular function required for stable gait over time. This study sought to quantify age-related differences in step-to-step control during prolonged walking using detrended fluctuation analysis (DFA). We hypothesized that step-to-step changes in step length and step width would exhibit reduced temporal persistence over time, with more pronounced effects in older than in younger adults.
View Article and Find Full Text PDFBMJ Neurol Open
September 2025
Wolfson Institute of Population Health, Queen Mary University of London, Centre for Preventive Neurology, London, England, UK.
Background: Nitrous oxide (N₂O)-related neurotoxicity is a significant public health concern among young people in the UK. Recognition necessitates timely diagnosis, abstinence from N₂O consumption and replacement of vitamin B12, usually via intramuscular (IM) hydroxocobalamin. This service development project evaluated a self-injection programme (SIP) compared with a nurse-led approach, within an established ambulatory care pathway, with the aim of improving treatment adherence and completion.
View Article and Find Full Text PDFJ Exerc Rehabil
August 2025
Faculty of Care and Rehabilitation, Seijoh University, Toukai, Japan.
Load asymmetry in the lower limbs of patients with hip fracture is associated with decreased gait ability, impaired balance, and increased risk of fall. The modified sit-to-stand (STS), which combines positioning the foot behind with chair seat elevation, facilitates loading on the affected limb. This study aimed to investigate lower limb load asymmetry during STS and walking in patients with hip fracture after modified STS training.
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