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Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction. | LitMetric
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Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction.

Marcos Díaz-Fernández , Manuel Algarra , Saturnino Calvo-Losada , José-Joaquín Quirante , Francisco Sarabia , María-Soledad Pino-González

Molecules

Department of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.

Published: August 2024

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Article Abstract

The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11357475PMC
http://dx.doi.org/10.3390/molecules29163864DOI Listing

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