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KDM8 prevents heart failure by controlling cardiac metabolism.
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KDM8 epigenetically controls cardiac metabolism to prevent initiation of dilated cardiomyopathy.
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Department of Translational Medicine, The Hospital for Sick Children, Toronto, Ontario Canada.
Cardiac metabolism is deranged in heart failure, but underlying mechanisms remain unclear. Here, we show that lysine demethylase 8 (Kdm8) maintains an active mitochondrial gene network by repressing , thus preventing dilated cardiomyopathy leading to lethal heart failure. Deletion of in mouse cardiomyocytes increased H3K36me2 with activation of and repression of target genes in the NAD pathway before dilated cardiomyopathy initiated.
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The prognosis of oral squamous cell carcinoma (OSCC) patients remains unclear, and a better understanding of the underlying molecular mechanisms is urgently required. Jumonji-C (JmjC) domain-containing protein 5 (JMJD5), renamed KDM8, has been implicated in tumorigenesis, circadian rhythm modulation, embryological development, and osteoclastogenesis. In the present study, we found that JMJD5 was over-expressed in patients with OSCC by real-time quantitative PCR (qPCR), western blot and immunohistochemical assays.
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