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http://dx.doi.org/10.1007/s12028-024-02095-y | DOI Listing |
J Biopharm Stat
September 2025
Biostatistics and Research Decision Sciences, Merck & Co. Inc., North Wales, Pennsylvania, USA.
A randomized clinical trial with multiple experimental groups and one common control group is often used to speed up development to select the best experimental regimen or to increase the chance of success of clinical trials. Most of the time, multiple dose levels of an experimental drug or multiple combinations of one experimental drug with other drugs comprise multiple experimental groups. Because the experimental drug appears in multiple comparisons with a shared control group, multiple testing adjustments to control the family-wise type I error rate are needed.
View Article and Find Full Text PDFSage Open Pediatr
September 2025
Department of Child Health, Hopexchange medical center, Kumasi, Ghana.
Background: Fever is a common condition in children under 5. Misconceptions surrounding its management can result in poor health outcomes.
Objectives: To assess caregivers' knowledge and home management practices regarding fever in children under 5 in the Northern Region of Ghana.
JAACAP Open
September 2025
Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Objective: Bipolar disorder (BD) diagnoses require episodes of hypomania and mania as well as depressive episodes. Given the overlap of BD symptoms with symptoms of other psychiatric conditions among youth, misdiagnosis is common. This topic was examined in a large sample of youth clinically referred for BD.
View Article and Find Full Text PDFScand J Surg
September 2025
Department of Gastrointestinal surgery, Stavanger University Hospital, Stavanger, Norway.
Background And Aims: Acute appendicitis is the most common surgical emergency worldwide. Obtaining a correct diagnosis and timely management can be challenging even in modern medicine. Hence, appendicitis is still considered a "high-risk" diagnosis for litigation and claims of malpractice.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Anesthesiology, Nan'an Hospital, Quanzhou City, China.
Pain, frailty, and the use of analgesic medications often occur together. Previous studies have demonstrated a strong link between them. The purpose of this study was to investigate the causal effects of pain and analgesic medication on frailty.
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