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Phosphaturic mesenchymal tumor (PMT) is a rare tumor causing bone complications and myopathy. Histologically, PMT displays a mix of spindled cells, osteoclast-like giant cells, basophilic matrix, and flocculent or "grungy" calcification. Here we describe a case of PMT in the right hip and proximal femur, initially suspected to be multiple myeloma, presenting with osteolytic lesions and elevated alkaline phosphatase. Tests for malignancy were negative, but a subsequent biopsy confirmed PMT. The patient underwent hip biopsy, femur resection, and hemiarthroplasty, with follow-up MRI recommended.
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http://dx.doi.org/10.1016/j.radcr.2024.07.036 | DOI Listing |
Ear Nose Throat J
September 2025
International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Introduction: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome that is characterized by hypophosphatemia resulting from the leakage of renal phosphate. Due to its diverse and nonspecific clinical manifestations, the diagnosis is often delayed.
Case Report: We present the rare case of a 33-year-old man with TIO who was presented with chronic bilateral hip joint pain and was initially misdiagnosed with osteonecrosis of the femoral head.
Pathol Res Pract
August 2025
Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic. Electronic address:
Aims: In recent years, molecular methods have emerged as valuable tools for identifying novel characteristics and recognizing extremely rare entities, thereby enhancing our understanding of their occurrence. In this case series, we present four exceptionally rare mesenchymal lesions affecting the knee region. Each case posed unique challenges, highlighting the pivotal role of molecular testing in achieving accurate diagnoses.
View Article and Find Full Text PDFBMC Musculoskelet Disord
September 2025
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Background: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by mesenchymal tumors that secrete fibroblast growth factor 23 (FGF23). Phosphaturic mesenchymal tumor (PMT) is a novel histopathologic entity that has been identified as a separate cause of TIO. Clinically, PMT is typically diagnosed late due to its rarity.
View Article and Find Full Text PDFSurg Pathol Clin
September 2025
Department of Pathology, Graduate Institute of Pathology, National Taiwan University Hospital, National Taiwan University College of Medicine, No 7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address:
Phosphaturic mesenchymal tumor (PMT) is a rare bone or soft tissue tumor. It exhibits distinctive morphologic features, including bland spindled cells, highly vascularized stroma, "smudgy or grungy" calcified matrix, and osteoclast-like giant cells. It is characterized by paraneoplastic tumor-induced osteomalacia through producing phosphatonins, especially FGF23.
View Article and Find Full Text PDFTurk Arch Otorhinolaryngol
July 2025
Eskişehir Osmangazi University Faculty of Medicine, Department of Radiology, Eskişehir, Türkiye.
Phosphaturic mesenchymal tumor (PMT) is a rare mesenchymal neoplasia usually located in the soft tissue and the bone. It is seen in older ages and is most commonly localized in the extremities. Here, we present a rare case of PMT located in the sinonasal region.
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