Osteolytic mystery: A rare case of pathologic fracture from a phosphaturic mesenchymal tumor in hip and femur.

Radiol Case Rep

Department of Radiological Sciences, University of California Irvine, Building 1, 101 The City Dr S, Orange, CA 92868 USA.

Published: October 2024


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Article Abstract

Phosphaturic mesenchymal tumor (PMT) is a rare tumor causing bone complications and myopathy. Histologically, PMT displays a mix of spindled cells, osteoclast-like giant cells, basophilic matrix, and flocculent or "grungy" calcification. Here we describe a case of PMT in the right hip and proximal femur, initially suspected to be multiple myeloma, presenting with osteolytic lesions and elevated alkaline phosphatase. Tests for malignancy were negative, but a subsequent biopsy confirmed PMT. The patient underwent hip biopsy, femur resection, and hemiarthroplasty, with follow-up MRI recommended.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342086PMC
http://dx.doi.org/10.1016/j.radcr.2024.07.036DOI Listing

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