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| http://dx.doi.org/10.1016/j.jcin.2024.07.022 | DOI Listing |
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Impact of Epicardial plaQUe Composition and geomeTry on Coronary hEmodynamics and Flow in Patients With Coronary Artery Disease (iEquate).
Catheter Cardiovasc Interv
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Royal North Shore Hospital, St Leonards, Australia.
Background: Invasive coronary physiology including fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and coronary flow reserve (CFR) are guideline-endorsed tools to guide the management of coronary artery disease (CAD). Complex factors impact and confound these assessments, and discordance between modalities complicates clinical management. iEquate is a prospective observational trial that combines multi-modality coronary physiology and optical coherence tomography (OCT) to identify the determinants of pressure-wire derived myocardial ischemia and iFR-FFR discordance.
View Article and Find Full Text PDFComparison of Anatomical and Physiological Indices of Angiographically Intermediate Left Main Coronary Artery Stenoses.
Am J Cardiol
September 2025
Faculty of Medicine, Istanbul University, Istanbul, Turkey; Department of Cardiology, Acibadem International Hospital, Istanbul, Turkey. Electronic address:
Although physiologic evaluation (e.g., fractional flow reserve) of intermediate lesions is well established in other coronary arteries, the left main coronary artery (LMCA) exhibits diagnostic challenges, hindering development of physiology-based decision-making algorithms.
View Article and Find Full Text PDFPrediction of graft patency during the year following coronary artery bypass grafting: preoperative computed tomography-derived fractional flow reserve versus intraoperative transit-time flow measurement.
J Thorac Cardiovasc Surg
August 2025
Cardiovascular Center, Myongji Hospital, Gyeonggido, Republic of Korea.
Background: Preoperative cardiac computed tomography-derived fractional flow reserve (CT-FFR) and intraoperative transit-time flow measurement (TTFM) values were compared with graft patency after coronary artery bypass grafting (CABG).
Methods: One hundred and eight patients who underwent isolated CABG using an in-situ internal thoracic artery (ITA) based composite graft and whose CT-FFR values were obtained were included. TTFM values(mean graft flow[MGF; mL/min], pulsatility index[PI], and diastolic filling percentage[DF%]) were obtained for each anastomosis in all study patients.
Diagnostic Value of Relative Flow Reserve in Patients With Prior Coronary Artery Disease: A Post Hoc Analysis of the PACIFIC-2 Trial.
Circ Cardiovasc Imaging
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Department of Cardiology, Amsterdam University Medical Centers, the Netherlands. (R.H., Y.B.O.S., R.W.W., R.A.J., P.K., P.A.D., R.S.D.).
Background: The relative flow reserve (RFR) derived from quantitative myocardial perfusion imaging is the ratio of absolute myocardial perfusion in a stenotic to normally perfused area and is considered the noninvasive equivalent of fractional flow reserve (FFR). In patients with prior coronary artery disease (CAD), detecting hemodynamically significant CAD using hyperemic myocardial blood flow (hMBF) is complicated by diffuse CAD and microvascular disease. In these patients, RFR may improve the diagnostic performance of myocardial perfusion imaging.
View Article and Find Full Text PDFFractional flow reserve vs angiography to guide percutaneous coronary intervention: an individual patient data meta-analysis.
Eur Heart J
August 2025
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Via di Grottarossa 1035, 00198, Rome Italy.
Background And Aims: Several randomized controlled trials (RCTs) have compared fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) with angiography-guided PCI in different clinical settings, yielding mixed results. This individual patient data meta-analysis focused on trials where FFR was used to assess intermediate coronary lesions in chronic coronary syndrome (CCS) or non-culprit vessels in non-ST-elevation acute coronary syndromes (NSTE-ACS).
Methods: Randomized controlled trials comparing FFR- vs angiography-guided PCI with a minimum follow-up of 1 year were searched.