Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The study of human working memory (WM) holds significant importance in neuroscience; yet, exploring the role of the medial temporal lobe (MTL) in WM has been limited by the technological constraints of noninvasive methods. Recent advancements in human intracranial neural recordings have indicated the involvement of the MTL in WM processes. These recordings show that different regions of the MTL are involved in distinct aspects of WM processing and also dynamically interact with each other and the broader brain network. These findings support incorporating the MTL into models of the neural basis of WM. This integration can better reflect the complex neural mechanisms underlying WM and enhance our understanding of WM's flexibility, adaptability, and precision.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tics.2024.07.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nuclear paxillin functions as a molecular switch for alternative splicing in neurons during a critical period of brain development.
EMBO J
September 2025
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
During a critical period of postnatal brain development, neural circuits undergo significant refinement coincident with widespread alternative splicing of hundreds of genes, which undergo altered splice site selection for the generation of isoforms essential for synaptic plasticity. Here, we reveal that neuronal activity-dependent phosphorylation of paxillin at its serine 119 (p-paxillin) acts as a molecular switch in the nucleus for the control of alternative splicing during this period. We show that following NMDA receptor activation, nuclear p-paxillin is recruited to nuclear speckles, where it interacts with splicing factors, such as U2AFs.
View Article and Find Full Text PDFObjectiveThis work examined performance costs for a spatial integration task when two sources of information were presented at increasing eccentricities with an augmented-reality (AR) head-mounted display (HMD).BackgroundSeveral studies have noted that different types of tasks have varying costs associated with the spatial proximity of information that requires mental integration. Additionally, prior work has found a relatively negligible role of head movements associated with performance costs.
View Article and Find Full Text PDFCompensatory cognitive training in the schizophrenia spectrum: A pilot study in an outpatient Mexican sample.
Appl Neuropsychol Adult
September 2025
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México.
Negative symptoms, depression, and cognitive impairments of the schizophrenia spectrum have been associated with difficulties in daily functioning. Compensatory Cognitive Training (CCT) has shown positive effects on cognition, negative symptoms, and functioning in this population. The main objective of this pilot study was to analyze the effects of CCT on cognition and functioning in a group schizophrenia spectrum outpatients in Mexico.
View Article and Find Full Text PDF[Children's brains with gender dysphoria. Effects of hormones and puberty blockers on a developing brain. An ethical approach].
Cuad Bioet
September 2025
Facultad de Farmacia y Nutrición de la Universidad de Navarra, Irunlarrea, 1, 31008 Pamplona.
In recent years, there has been a significant increase in minors with gender dysphoria (GD) seeking transition treatments, including puberty blockers and cross-sex hormones. The developing child's brain exhibits structural and functional differences in children with GD compared to cisgender children, particularly in areas where sex differences exist. Brain development during childhood and adolescence is strongly influenced by sex hormones.
View Article and Find Full Text PDFSmart load balancing in cloud computing: Integrating feature selection with advanced deep learning models.
PLoS One
September 2025
College of Business Administration, Northern Border University (NBU), Arar, Kingdom of Saudi Arabia.
The increasing dependence on cloud computing as a cornerstone of modern technological infrastructures has introduced significant challenges in resource management. Traditional load-balancing techniques often prove inadequate in addressing cloud environments' dynamic and complex nature, resulting in suboptimal resource utilization and heightened operational costs. This paper presents a novel smart load-balancing strategy incorporating advanced techniques to mitigate these limitations.
View Article and Find Full Text PDF