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Commentary on "Outcomes of Allogenic Umbilical Cord Mesenchymal Stem Cell infusion for Liver Cirrhosis due to Biliary Atresia after Kasai Operation" JPEDSURG-D-25-00654R2.
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Dept. of Paediatric Surgery, Kings College Hospital, London, UK. Electronic address:
Outcomes of Allogenic Umbilical Cord Mesenchymal Stem Cell infusion for Liver Cirrhosis due to Biliary Atresia after Kasai Operation.
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Children's Hospital 2, Ho Chi Minh City, Vietnam. Electronic address:
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View Article and Find Full Text PDF[Primary biliary cholangitis-Update on diagnostics, risk stratification and new treatment options].
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Bereich Hepatologie, Medizinische Klinik II, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Primary biliary cholangitis (PBC) is a chronic inflammatory, autoimmune-mediated liver disease that progresses to fibrosis and cirrhosis if left untreated. In addition to preventing complications, the management of burdensome symptoms, particularly pruritus, represents a key therapeutic goal. Ursodeoxycholic acid (UDCA) is the established first-line treatment; however, up to 40% of patients show an inadequate response and require second-line treatment.
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Introduction: Failure to rescue (FTR) is mortality after a major complication. FTR may be an effective quality metric in liver transplantation (LT). However, there is a paucity of nationwide data on the rates and effects of FTR on outcomes.
View Article and Find Full Text PDFMicroRNA-126-3p as a predictive biomarker for patients with primary biliary cholangitis refractory to ursodeoxycholic acid.
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Senior Department of Infectious Diseases, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China.
Background: Ursodeoxycholic acid (UDCA) is the first-line therapeutic agent for primary biliary cholangitis (PBC). However, a subset of patients exhibit a suboptimal response to UDCA, and reliable predictive biomarkers remain elusive. Studies have implicated plasma microRNAs (miRNAs) in the pathophysiological progression of PBC, with certain miRNAs demonstrating potential as diagnostic and disease progression biomarkers.
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