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Article Abstract
To investigate the different impact of each component of lipid profile in advanced cancer patients treated with immune checkpoints inhibitors (ICIs) according to neutrophil-to-lymphocyte ratio (NLR) value. We retrospectively collected total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDL), high-density lipoproteins (HDL). 407 patients were enrolled. In NLR <4 subgroup, TGs <150 mg/dl led to longer PFS ( = 0.01) and OS ( = 0.02) compared with TGs ≥150 mg/dl; LDL <100 mg/dl led to longer PFS ( = 0.004) and OS ( = 0.007) compared with LDL ≥100 mg/dl. In NLR ≥4 subgroup, TC >200 mg/dl led to longer PFS ( = 0.008) and OS ( = 0.004) compared with TC <200 mg/dl. We showed a distinct prognostic impact of lipid profile according to NLR.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457594 | PMC |
| http://dx.doi.org/10.1080/1750743X.2024.2377953 | DOI Listing |
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