Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The design of three-dimensional (3D) scaffolds should focus on creating highly porous, 3D structures with an interconnected pore network that supports cell growth. The scaffold's pore interconnectivity is directly linked to vascularization, cell seeding, guided cell migration, and transportation of nutrients and metabolic waste. In this study, different types of food flavors including monosodium glutamate, sugar, and sodium chloride were used as the porogens along with PCL/PVP blend polymer for solvent casting/particulate leaching method. The morphology, porosity, interconnectivity, chemical composition, water absorption, and mechanical properties of the fabricated scaffolds are carefully characterized. The scaffolds are biocompatible in bothandexperiments and do not trigger any inflammatory response while enhancing new bone formation and vascularization in rabbit calvaria critical-sized defects. The new bone merges and becomes denser along with the experiment timeline. The results indicate that the 3D PCL/PVP scaffolds, using monosodium glutamate as porogen, exhibited suitable biological performance and held promise for bone tissue engineering in oral and maxillofacial surgery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1088/1748-605X/ad6ac5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Discovery of novel umami-enhancing peptides in through multi-level virtual screening, multisensory evaluation, electronic tongue, and molecular simulation.
Food Chem X
August 2025
College of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, China.
This study utilized integrated sensory-guided, machine learning, and bioinformatics strategies identify umami-enhancing peptides from , investigated their mechanism of umami enhancement, and confirmed their umami-enhancing properties through sensory evaluations and electronic tongue. Three umami-enhancing peptides (APDGLPTGQ, SDDGFQ, and GLGDDL) demonstrated synergistic/additive effects by significantly enhancing umami intensity and duration in monosodium glutamate (MSG). Furthermore, molecular docking showed that these umami-enhancing peptides enhanced both the binding affinity and interaction forces between MSG and the T1R1/T1R3 receptor system, thereby enhancing umami perception.
View Article and Find Full Text PDFSpirulina subsalsa powder produced from seawater-wastewater: a nutrient-rich and safe alternative for aquaculture feed.
Bioresour Technol
September 2025
School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China; Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China; Shandong Provincial Engineering Center on Environmental Science and Technology, Jinan 250061, China; Institute o
Elevated expense of chemical media spurs a shift to non-chemical media in microalgal cultivation, while ensuring the safety of the resulting powder poses a challenge. No previous studies have evaluated the safety and application of Spirulina subsalsa powder cultivated in monosodium glutamate wastewater (MSGW) and seawater. In this study, an analysis of basic nutritional components in Spirulina subsalsa powder indicated that this algal powder had high protein content, low lipid content and rich mineral content.
View Article and Find Full Text PDF[ acupuncture modulates Glu/GABA‑Gln metabolic loop abnormalities in insomniac rats].
Nan Fang Yi Ke Da Xue Xue Bao
August 2025
Department of Nursing, Shenzhen Hospital, Southern Medical University, Shenzhen 518101, China.
Objectives: To investigate the therapeutic effect of acupuncture in a rat model of insomnia and its regulatory effect on the glutamic acid (Glu)/γ-aminobutyric acid (GABA)-glutamine (Gln) metabolic loop.
Methods: Forty male SD rats were randomly assigned to control group, model group, group and group (=10). In the latter 3 groups, rat models of insomnia were established by intraperitoneal injections of p-chlorophenylalanine and verified using a sodium pentobarbital-induced sleep test.
Mutant alleles enable a D-glutamate auxotroph to grow with lower requirements for exogenous D-glutamate.
Microbiol Spectr
September 2025
Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
D-glu is a key component of peptidoglycan (PG) and is essential for growth in most bacteria. To assess constraints on PG evolution and bacterial requirements for D-glu, we sought to artificially evolve PG biosynthesis, leading to either replacement of D-glu in the PG peptide or alternative pathways to D-glu incorporation. We previously found that suppression of D-glu auxotrophy in a mutant of grown on lysogeny broth salts (LBS) medium was rare but could be accomplished by mutation of , with restoration of wild-type PG structure.
View Article and Find Full Text PDFModulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging.
Front Aging Neurosci
August 2025
Diabetes Center and Department of Anatomy, University of California, San Francisco, San Francisco, CA, United States.
Effective communication between the brain and peripheral tissues is crucial for homeostasis and health, and its impairment is a defining feature of aging. Circumventricular organs, characterized by the presence of fenestrated capillaries and absence of a blood-brain barrier (BBB), play a crucial role in controlling substance exchange between the brain and the blood. To date, adaptive changes in fenestrated vasculature in response to environmental insults remain poorly understood.
View Article and Find Full Text PDF