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http://dx.doi.org/10.4093/dmj.2024.0312 | DOI Listing |
Intern Emerg Med
September 2025
Department of Health Policy, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, 20156, Milan, Italy.
Health systems in Europe are under growing budgetary pressures to provide appropriate and affordable healthcare for their populations. At the same time, there is a worsening workforce crisis from the supply side among clinical roles, and there has been an expansion of new health professions in many countries. The current shortage of physicians in many European countries has become a matter of widespread concern at political and societal level.
View Article and Find Full Text PDFAdv Ther
September 2025
Bristol Myers Squibb, Princeton, NJ, 08540, USA.
Background And Objectives: Deucravacitinib, a first-in-class, oral, selective, allosteric tyrosine kinase 2 inhibitor, demonstrated efficacy across the primary endpoint and all key secondary endpoints in the phase 2 PAISLEY SLE trial in patients with active systemic lupus erythematosus (SLE). Here, we describe 2 phase 3 trials [POETYK SLE-1 (NCT05617677), POETYK SLE-2 (NCT05620407)] which will assess the efficacy and safety of deucravacitinib in patients with active SLE. These phase 3 trials have been designed to replicate the successful elements of the phase 2 trial, including its glucocorticoid-tapering strategy and disease activity adjudication.
View Article and Find Full Text PDFCell Tissue Bank
September 2025
Department of Ophthalmology and Visual Sciences, McGill University, Montreal, Canada.
To summarize the evidence examining the outcomes of Descemet membrane endothelial keratoplasty (DMEK) using eye bank pre-stripped versus surgeon prepared grafts. Systematic review and meta-analysis. This study was conducted following the preferred reporting items for systematic reviews and meta-analyses consensus statement (PROSPERO ID: CRD42023457120).
View Article and Find Full Text PDFClin Res Cardiol
September 2025
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Objectives: We investigated changes in lipid-lowering drug prescriptions in Germany as a whole and in the 16 federal states over the last 13 years and their association with hospitalization rates for acute myocardial infarction.
Design: Ecological study.
Setting: Nationwide German hospitalization, Diagnosis-Related Groups Statistic.
Osteoporos Int
September 2025
International Osteoporosis Foundation, Nyon, Switzerland.
Unlabelled: The study explored osteoporosis patients' views on the disease in six LATAM countries. All were diagnosed for over 3 years, 65% avoiding fragility fractures. Sixteen used osteoporosis drugs, trusting physicians most.
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