98%
921
2 minutes
20
Clinical guidelines are evidence-based recommendations developed by healthcare organizations or expert panels to assist healthcare providers and patients in making appropriate and reliable decisions regarding specific health conditions, aiming to enhance the quality of healthcare by promoting best practices, reducing variations in care, and at the same time, allowing tailored clinical decision-making. European Hernia Society (EHS) guidelines aim to provide surgeons a reliable set of answers to their pertinent clinical questions and a tool to base their activity as experts in the management of abdominal wall defects. The traditional approach to guideline production is based on gathering key opinion leader in a particular field, to address a number of key questions, appraising papers, presenting evidence and produce final recommendations based on the literature and consensus. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) method offers a transparent and structured process for developing and presenting evidence summaries and for carrying out the steps involved in developing recommendations. Its main strength lies in guiding complex judgments that balance the need for simplicity with the requirement for complete and transparent consideration of all important issues. EHS guidelines are of overall good quality but the application of GRADE method, began with EHS guidelines on open abdomen, and the increasing adherence to the process, has greatly improved the reliability of our guidelines. Currently, the need to application of this methodology and the creation of stable and dedicated group of researchers interested in following GRADE in the production of guidelines has been outlined in the literature. Considering that the production of clinical guidelines is a complex process, this paper aim to highlights the primary features of guideline production, GRADE methodology, the challenges associated with their adoption in the field of hernia surgery and the project of the EHS to establish a stable guidelines committee to provide technical and methodological support in update of previously published guideline or the creation of new ones.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272451 | PMC |
http://dx.doi.org/10.3389/jaws.2024.13007 | DOI Listing |
Neotrop Entomol
September 2025
College of Optometry, University of Houston, Houston, TX, USA.
Lucilia sericata (Meigen, 1826) maggot excretions/secretions (ES) have demonstrated anti-inflammatory and wound healing potential on corneal epithelial cells. This study aimed to evaluate the in vitro antibacterial potential of the ES against clinically relevant Gram-negative Pseudomonas aeruginosa and Gram-positive Staphylococcus epidermidis in the presence of human tear fluid. The ES was collected from sterile first- and second-instar L.
View Article and Find Full Text PDFBMC Psychol
September 2025
Behavioral Epidemiology, Institute of Clinical Psychology and Psychotherapy, TUD Dresden University of Technology, Chemnitzer Straße 46, 01187, Dresden, Germany.
Background: Disruptive behavior and emotional problems - especially anxiety - are common in children and frequently co-occur. However, the role of co-occurring emotional problems in disruptive behavior intervention response is unclear. This study aimed to compare the effectiveness of an indicated prevention program in children with disruptive behavior problems with vs.
View Article and Find Full Text PDFJ Abdom Wall Surg
August 2025
Department of Surgery, Papageorgiou General Hospital, Thessaloniki, Greece.
Stem Cell Res Ther
August 2025
Advanced Therapy Medicinal Product Technology Development Center (ATMP-TDC), Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Background: Mesenchymal stem/stromal cells (MSCs) or MSC-derived extracellular vesicles (MSC-EVs) are considered potential modulators of the immune system in type 1 diabetes (T1D) therapy. On the other hand, preconditioning MSCs with inflammatory agents is a promising strategy to improve the therapeutic effects of these cells. Therefore, we performed various direct preconditioning regimens (IFN-γ, poly(I: C), LPS, and hypoxia) on clonal MSCs (cMSCs), and for indirect preconditioning regimens, the same regimens were applied to peripheral blood mononuclear cells (PBMCs).
View Article and Find Full Text PDFJ Abdom Wall Surg
August 2025
Department of Robotic Pancreaticobiliary and Abdominal Wall Reconstruction Unit, University Hospitals of Derby and Burton, Derby, United Kingdom.
Background: Robotic-assisted surgery (RAS) for abdominal wall hernia repair is an established, minimally invasive technique that is in the early phase of adoption within the UK. We aimed to demonstrate the impact on patient outcomes and safety of hernia repair by adhering to the robotic abdominal wall surgery pathway developed by the European Hernia Society.
Materials And Methods: Two experienced laparoscopic surgeons in the UK underwent four phases that involved preclinical and clinical phases.