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Background: The outcomes of revision total hip arthroplasty (rTHA) have become increasingly important as their volume increases. Computer navigation, a reliable method to improve component positioning during primary total hip arthroplasty (THA), is not well studied in the rTHA setting. Given that dislocation rates following rTHA are significantly higher than those of primary THA, component positioning becomes paramount in these cases.
Methods: Here, we present two case reports and surgical techniques, one of a 77-year-old man undergoing rTHA for recurrent hip instability following primary THA, and one of a 61-year-old woman undergoing rTHA for severe iliopsoas bursitis who was at increased risk for instability and dislocation given her history of large segment spinal fusion.
Results: Both patients achieved optimal acetabular component positioning after rTHA with imageless computer navigation.
Conclusions: The use of imageless computer navigation in rTHA provides accurate and reproducible component positioning during acetabular rTHA.
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http://dx.doi.org/10.1016/j.artd.2024.101347 | DOI Listing |
Med Eng Phys
October 2025
Department of Engineering Science, University of Oxford, United Kingdom. Electronic address:
Traditionally, clinical devices are designed, tested and improved through lengthy and expensive laboratory experiments and clinical trials [1]. More recently, computational methods have allowed for rapid testing, speeding up the design process and enabling far more complete searches of design space. While computational models cannot fully capture the complexities of biological systems, they provide valuable insights into crucial underlying mechanisms, such as the effects of fluid-structure interactions (FSIs).
View Article and Find Full Text PDFJ Nucl Med Technol
September 2025
Institute of Nuclear Medicine, First Faculty of Medicine, Charles University and the General University Hospital in Prague, Prague, Czech Republic;
The aim of the study was to validate a new method for semiautomatic subtraction of [Tc]Tc-sestamibi and [Tc]NaTcO SPECT 3-dimensional datasets using principal component analysis (PCA) against the results of parathyroid surgery and to compare its performance with an interactive method for visual comparison of images. We also sought to identify factors that affect the accuracy of lesion detection using the two methods. Scintigraphic data from [Tc]Tc-sestamibi and [Tc]NaTcO SPECT were analyzed using semiautomatic subtraction of the 2 registered datasets based on PCA applied to the region of interest including the thyroid and an interactive method for visual comparison of the 2 image datasets.
View Article and Find Full Text PDFJ Mol Model
September 2025
Department of Electronics and Communication Engineering, National Institute of Technology Patna, Patna, Bihar, India.
Context: This study investigates the radiation tolerance of a SiGe source vertical tunnel field effect transistor (VTFET) under heavy ion-induced single event effects (SEEs). Single event effects (SEEs) occur when high-energy particles interact with semiconductor devices, leading to unintended behavior. The effect of high energy ions on the VTFET is examined for various linear energy transfer (LET) values and at multiple ion hit locations.
View Article and Find Full Text PDFAging Cell
September 2025
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
The CST (CTC1-STN1-TEN1) complex, a single-stranded DNA (ssDNA) binding complex, is essential for telomere maintenance and genome stability. Depletion of either CTC1 or STN1 results in cellular senescence, while mutations in these components are associated with severe hereditary disorders. In this study, we demonstrate that the direct STN1-CTC1 interaction stabilizes CTC1 by preventing its degradation via TRIM32 mediated ubiquitination.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
Photoremovable protecting groups (PRPGs) enable precise spatiotemporal control over molecular release and functional activation. Recent advances have introduced wavelength-selective systems for sequential deprotection, broadening applications in drug delivery, material synthesis, and photopolymerization. In parallel, PRPGs play a crucial role in photobase generators (PBGs) and photoacid generators (PAGs), enabling oxygen-tolerant, spatially controlled polymerization and depolymerization through light-induced base and acid release.
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