Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Colorectal cancer (CRC) is the third most common cancer worldwide. The role of intestinal microbiota in carcinogenesis has also become an important research topic, and CRC is closely related to the intestinal microbiota. Selenium-containing compounds have attracted more attention as anticancer drugs as they can have minimal side effects. The purpose of this study was to determine and compare the effect of sodium selenite and selenomethionine on the microbial communities of nude mice with CRC. A CRC ectopic tumorigenesis model was established by subcutaneously injecting HCT116 cells into nude mice. The mice were then intraperitoneally injected with sodium selenite and selenomethionine for 24 days to regulate their intestinal microbiota. Compared with sodium selenite, selenomethionine resulted in a greater reduction in the richness and diversity of intestinal microbiota in nude mice with CRC, and the richness and diversity were closer to healthy levels. Selenomethionine also regulated a wider variety of flora. Additionally, sodium selenite and selenomethionine produced different microorganisms, changed function and metabolic pathways in the intestinal microbiota. Both sodium selenite and selenomethionine have certain effects on restoring the intestinal microbial diversity in nude mice with CRC, and the effect of selenomethionine is better than that of sodium selenite.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11279152 | PMC |
| http://dx.doi.org/10.3390/microorganisms12071336 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of different selenium fertilizer types and dosages on non-volatile organic acids and aroma substances of flue-cured tobacco.
Front Plant Sci
August 2025
College of Agriculture, South China Agricultural University, Guangzhou, China.
Tobacco ( L.) is well-known as an economic crop whose quality is evaluated according to its aroma quality. Researchers have found that selenium application can increase the aroma quality of tobacco, but until now, its mechanism is still unclear.
View Article and Find Full Text PDFEffect of foliar sodium selenite fertilization on oxidative stress and productivity in Olea europaea L., biofortification and quality of extra virgin olive oil.
J Sci Food Agric
September 2025
Universidade Federal do Pampa, Campus São Gabriel-São Gabriel, São Gabriel, Brazil.
Background: Fertilization of plants with selenium (Se) can enhance their resistance to abiotic stresses and improve human health and nutrition. However, Se fertilization in olive trees remains underexplored. This study evaluated the effect of foliar sodium selenite fertilization on leaf Se content, oxidative stress, olive tree productivity, biofortification of extra virgin olive oils (EVOO), and their physicochemical and antioxidant attributes in two mature 'Arbequina' olive orchards.
View Article and Find Full Text PDFSelenite protects human peripheral blood mononuclear cells (PBMCs) from CdCl cytotoxicity.
J Trace Elem Med Biol
August 2025
Department of Biochemistry and Molecular Biology, Center for Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil; Federal University of Rio Grande do Sul, Departamento of Biochemistry, Porto Alegre, RS, Brazil. Electronic address:
The potential role of selenium (Se) in modulating cadmium (Cd) cytotoxicity in human peripheral blood mononuclear cells (PBMCs) was investigated by assessing pro- and anti-inflammatory as well as redox biomarkers. We also examined the potential synergistic effects of SARS-CoV-2 N-protein with Cd in PBMCs. PBMCs were isolated from adults and treated for 48 h with sodium selenite (Na₂SeO₃; 0.
View Article and Find Full Text PDFThe protective effect of sodium selenite against silver nanoparticles induced oxidative stress and autophagy in cardiomyocytes is associated with AMPK/mTOR signaling pathway.
Nanotoxicology
August 2025
Department of General Medicine, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.
Selenite(Se) is a trace mineral that is essential for cardiac health. This study aims to investigate the beneficial effects of Se on cardiomyocyte damage induced by silver nanoparticles (AgNPs) and to explore the underlying protective mechanisms. H9C2 cells were incubated with AgNPs with or without Se .
View Article and Find Full Text PDFSelenium Enhances Osteogenic Differentiation and Mineralization in Human Osteoblasts: Implications for Bone Health and Metabolism.
Curr Med Chem
August 2025
Department of Medical Services and Techniques, Yunus Emre Vocational School of Health Services, Anadolu University, Eskisehir, Türkiye.
Introduction: Sodium Selenite (NaSe) is a molecule with various biological activities. Bone fractures and osteoporotic diseases are increasingly common health issues, prompting the search for alternative treatments. Therefore, the purpose of this study was to examine the antioxidant and osteogenic properties of NaSe.
View Article and Find Full Text PDF