98%
921
2 minutes
20
Dyspnea is one of the most common and distressing symptoms in patients with cancer and noncancer advanced diseases. The Japanese Society for Palliative Medicine revised previous guidelines for the management of respiratory symptoms in patients with cancer and newly developed clinical guidelines for managing dyspnea in patients with advanced disease, based on the result of systematic reviews for each clinical question and consensus among experts. We describe the recommendations of the guidelines as well as provide insights into the reasoning behind the recommendations and their development process. There has been a paucity of evidence regarding the interventions for dyspnea in patients with advanced disease. Thus, more clinical research that includes not only randomized controlled trials but also real-world observational studies is warranted.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1089/jpm.2023.0667 | DOI Listing |
World Neurosurg
September 2025
Department of Neurosurgery, Independent Public Specialist Western Hospital John Paul II in Grodzisk Mazowiecki, Daleka 11, 05-825, Grodzisk Mazowiecki, PL. Electronic address:
Introduction: Anterior cervical discectomy and fusion (ACDF) is a common surgical procedure used to treat herniated discs, degenerative disc disease, and nerve root compression in the cervical spine. This systematic literature review aims to analyze the available literature on the incidence, risk factors, clinical considerations, and available therapies for spinal epidural hematoma (SEH) following ACDF.
Methods: A systematic search was conducted in PubMed, Google Scholar, and Embase from database inception to June 18, 2025, following the PRISMA guidelines.
Clin Neurol Neurosurg
September 2025
Department of Internal Medicine, Baylor Scott and White Health, Temple, TX, USA.
Background: Carotid artery stenosis prevalence increases with age, and carotid endarterectomy (CEA) is a possible treatment option. However, nonagenarians are at high risk of experiencing postoperative complications and are often not considered surgical candidates. We aimed to identify risk factors associated with postoperative myocardial infarction (MI), stroke, and death within 30 days for nonagenarians undergoing CEA and to analyze the predictive ability of modified frailty indices (mFI) in predicting adverse outcomes for this population.
View Article and Find Full Text PDFJ Physiol
September 2025
Institue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.
Some patients with heart failure with preserved ejection fraction (HFpEF) have demonstrated evidence of exercise-induced arterial hypoxaemia (EIAH). However, EIAH was not quantified using , , and measurements as previously conducted in healthy adults nor was EIAH quantified alongside simultaneous measurements of pulmonary vascular pressures, cardiorespiratory responses, or dyspnoea on exertion (DOE) in these patients. Given the effects of hypoxaemia on pulmonary vasoconstriction, cardiorespiratory responses, and DOE, we tested the hypothesis that patients with HFpEF and EIAH (EIAH) would demonstrate higher pulmonary vascular pressures, worse oxygen uptake, and greater DOE compared with patients without EIAH (EIAH).
View Article and Find Full Text PDFJ Pain Symptom Manage
September 2025
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland and Department of Palliative Care Centre and Home Hospital Services, Tampere University Hospital, The Wellbeing Services County of Pirkanmaa, Finland.
Context: High-flow nasal therapy (HFNT) may relieve severe dyspnea, but its role compared to other treatment options in palliative care remains unclear.
Objectives: Assess the effect and feasibility of HFNT with air compared to fan therapy in relieving dyspnea among non-hypoxemic patients with incurable cancer.
Methods: This prospective, randomized, controlled, crossover trial compared airflow delivered by HFNT and fan.
JACC Case Rep
September 2025
Division of Cardiothoracic Surgery, Department of Surgery, University of California San Francisco, San Francisco, California, USA; Department of Cardiac Surgery, Kaiser San Francisco Medical Center, San Francisco, California, USA. Electronic address:
Background: Kimura disease is a rare inflammatory condition that typically manifests with subcutaneous nodules of the head and neck. This is the first documented case of intracardiac Kimura disease.
Case Summary: A 57-year-old woman presented with a heart murmur and dyspnea.