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Introduction: Objective of this study was to assess the diagnostic efficacy of the most commonly used radiological evaluation in form of contrast enhanced computed tomography of abdomen with adrenal protocol, basic functional evaluation and surgical outcomes of primary adrenal masses.
Material And Methods: We have retrospectively analysed the institutional records of 108, patients admitted from August 2017 to September 2023, who had underwent surgical intervention for their adrenal mass after thorough evaluation and stabilization.
Results: Flank pain was the most common symptoms in 44 (40.74%) patients. Non-functional adrenal adenoma was found in 36 (33.33%) patients. Pheochromocytoma was the most the common functional adrenal mass found in 24 (22.22%) patients. CECT abdomen had suggested features of malignancy in 16(14.81%) patients. In final histopathological report 26(24.07%) patients had pheochromocytoma and 12 (11.11%) patients had adrenocortical carcinoma. CECT abdomen had sensitivity of 75%, specificity of 95.6%. Plasma free metanephrines and normetanephrine analysis had shown sensitivity of 90%, specificity of 92.86%, aldosterone to renin ratio had sensitivity of 92%, specificity of 100%. Sensitivity and specificity of the low-dose dexamethasone suppression test and plasma dehydroepiandrosterone was 100% in our study. Eighty patients (74.07%) were operated with laparoscopic adrenalectomy, 20 (18.52%) patients with open adrenalectomy. Eight patients (7.41%) were converted from laparoscopic to open. Laparoscopic approach had significantly lesser mean operating time, lesser blood loss, lesser hospitalization and lesser post-operative complications.
Conclusion: Radiological analysis and functional analysis has shown good sensitivity and high specificity. Laparoscopic approach has advantage of lesser operative time, lesser hospitalization and lesser post-operative complications.
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http://dx.doi.org/10.1177/03915603241259881 | DOI Listing |
Front Endocrinol (Lausanne)
September 2025
Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Isolated ectopic secretion of corticotropin-releasing hormone (CRH) is an exceedingly rare cause of Cushing's syndrome (CS), accounting for fewer than 1% of cases. Ectopic CS is an uncommon but potentially life-threatening condition that often necessitates urgent diagnostic evaluation and treatment. Hormonal testing may suggest a pituitary origin, complicating the diagnostic process.
View Article and Find Full Text PDFEarly Hum Dev
September 2025
Sivas Cumhuriyet University, Faculty of Medicine, Department of Pediatric Endocrinology, Sivas, Türkiye.
Background: The appearance of pubic or axillary hair before the age of eight in girls or nine in boys, without other signs of puberty, is defined as premature adrenarche (PA) and may be an early sign of the metabolic syndrome. The second to fourth digit ratio (2D:4D), thought to reflect prenatal androgen exposure, has been associated with a variety of behavioral, metabolic, and hormonal conditions.
Objective: To evaluate the relationship between 2D:4D digit ratios and anthropometric, metabolic, and hormonal parameters in children with PA.
Eur J Endocrinol
September 2025
Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, 55905.
Objective: Identify social/metabolic risk factors associated with subsequent diagnosis of adrenal adenoma.
Design: Population-based historical case-control study.
Methods: Cases were adult patients diagnosed with an adrenal adenoma between 2005-2017 with no overt hormone excess.
Minerva Endocrinol (Torino)
September 2025
Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden -
Adrenal cysts are rare lesions that are increasingly discovered incidentally during radiological examinations conducted without suspicion of adrenal disease. Typically benign, hormonally nonfunctional, and asymptomatic, these lesions may occasionally manifest mass effect symptoms such as pain or abdominal discomfort, particularly in large cysts. Management approaches vary from no follow-up to hormonal investigation, imaging follow-up, or adrenalectomy, especially if the cyst is growing or exhibits an atypical appearance.
View Article and Find Full Text PDFJ Clin Endocrinol Metab
September 2025
National Institutes of Health Clinical Center, National Institutes of Health.
Context: Testicular adrenal rest tumors (TART) frequently develop and are the most common cause of male infertility in classic congenital adrenal hyperplasia (CAH). Little is known about the natural course.
Objective: We aimed to investigate age of onset, associated factors, and characterize the sonographic natural history of TART in males with classic CAH followed prospectively from childhood to adulthood.