Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Post-stroke upper limb (UL) motor improvement is associated with adaptive neuroplasticity and motor learning. Both intervention-related (including provision of intensive, variable, and task-specific practice) and individual-specific factors (including the presence of genetic polymorphisms) influence improvement. In individuals with stroke, most commonly, polymorphisms are found in Brain Derived Neurotrophic Factor (BDNF), Apolipoprotein (APOE) and Catechol-O-Methyltransferase (COMT). These involve a replacement of cystine by arginine (APOEε4) or valines by 1 or 2 methionines (BDNF:valmet, metmet; COMT:valmet; metmet). However, the implications of these polymorphisms on post-stroke UL motor improvement specifically have not yet been elucidated.
Objective: Examine the influence of genetic polymorphism on post-stroke UL motor improvement.
Design: Systematic Review and Meta-Analysis.
Methods: We conducted a systematic search of the literature published in English language. The modified Downs and Black checklist helped assess study quality. We compared change in UL motor impairment and activity scores between individuals with and without the polymorphisms. Meta-analyses helped assess change in motor impairment (Fugl Meyer Assessment) scores based upon a minimum of 2 studies/time point. Effect sizes (ES) were quantified based upon the Rehabilitation Treatment Specification System as follows: small (0.08-0.18), medium (0.19 -0.40) and large (≥0.41).
Results: We retrieved 10 (4 good and 6 fair quality) studies. Compared to those with BDNF valmet and metmet polymorphism, meta-analyses revealed lower motor impairment (large ES) in those without the polymorphism at intervention completion (0.5, 95% CI: 0.11-0.88) and at retention (0.58, 95% CI:0.06-1.11). The presence of CoMT valmet or metmet polymorphism had similar results, with lower impairment (large ES ≥1.5) and higher activity scores (large ES ranging from 0.5-0.76) in those without the polymorphism. Presence of APOEε4 form did not influence UL motor improvement.
Conclusion: Polymorphisms with the presence of 1 or 2 met alleles in BDNF and COMT negatively influence UL motor improvement.
Registration: https://osf.io/wk9cf/.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268047 | PMC |
| http://dx.doi.org/10.1177/11795735241266601 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ant visual route navigation: How the fine details of behaviour promote successful route performance and convergence.
PLoS Comput Biol
September 2025
Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
Individually foraging ants use egocentric views as a dominant navigation strategy for learning and retracing routes. Evidence suggests that route retracing can be achieved by algorithms which use views as 'visual compasses', where individuals choose the heading that leads to the most familiar visual scene when compared to route memories. However, such a mechanism does not naturally lead to route approach, and alternative strategies are required to enable convergence when off-route and for correcting on-route divergence.
View Article and Find Full Text PDFDistinct cerebellar networks underpin clinical improvement in adolescent Tourette disorder.
Brain
September 2025
Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 75013 Paris, France.
Adolescence is frequently called the second brain maturation period. In Tourette disorder (TD), the clinical trajectory of tics and associated psychiatric co-morbidities vary significantly across individuals during the transition from adolescents to adulthood. In this study, we aimed to identify patterns of resting-state functional connectivity that differentiate adolescents with TD from their neurotypical peers, and to monitor symptom-specific functional changes over time.
View Article and Find Full Text PDFPreclinical and first-in-human evidence of 4-hydroxybenzoic acid for mitochondrial COQ2 deficiency.
Brain
September 2025
Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, 18016 Granada, Spain.
Primary coenzyme Q (CoQ) deficiency is a mitochondrial disorder with variable clinical presentation and limited response to standard CoQ10 supplementation. Recent studies suggest that 4-hydroxybenzoic acid (4-HBA), a biosynthetic precursor of CoQ, may serve as a substrate enhancement treatment in cases caused by pathogenic variants in COQ2, a gene encoding a key enzyme in CoQ biosynthesis. However, it remains unclear whether 4-HBA is required throughout life to maintain health, whether it offers advantages over CoQ10 treatment, and whether these findings are translatable to humans.
View Article and Find Full Text PDFCombining Therapeutic Strategies to Treat the Injured Spinal Cord: A Translational Perspective.
J Neurotrauma
September 2025
Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, California, USA.
Spinal cord injury (SCI) results in an array of debilitating, sometimes permanent-and at times life-threatening-motor, sensory, and autonomic deficits. A broad range of therapies have been tested pre-clinically, and there has been a significant acceleration in recent years of clinical translation of potential treatments. However, it is widely appreciated among scientists and clinical professionals alike that there likely is no "silver bullet" (single treatment) that will result in complete functional restoration after SCI.
View Article and Find Full Text PDFContrastive Learning Model for Wearable-based Ataxia Assessment.
IEEE Trans Biomed Eng
September 2025
Objective: Frequent and objective assessment of ataxia severity is essential for tracking disease progression and evaluating the effectiveness of potential treatments. Wearable-based assessments have emerged as a promising solution. However, existing methods rely on inertial data features directly correlated with subjective and coarse clinician-evaluated rating scales, which serve as imperfect gold standards.
View Article and Find Full Text PDF