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http://dx.doi.org/10.1016/j.jtha.2024.03.028 | DOI Listing |
Adv Healthc Mater
August 2025
Key Laboratory of Cluster Science, Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Advanced Research Institute of Multidisciplinary Science, Frontiers Science Center for High Energy Material, Advanced Technology Research Institute (Jinan), Schoo
Preventing coagulation during extracorporeal blood circulation is critical for clinical treatments. Developing anticoagulant materials for key components can reduce reliance on systemic anticoagulants and improve safety. However, such materials often show limited efficacy due to inefficient interactions with pro/anti-coagulation components, resulting from random active site distribution and orientation.
View Article and Find Full Text PDFToxins (Basel)
August 2025
Adaptive Biotoxicology Lab, School of the Environment, University of Queensland, St. Lucia, QLD 4072, Australia.
Venoms of the Palearctic vipers in the genus cause severe procoagulant clinical effects, yet the precise molecular targets remain incompletely defined. To fill this toxicological knowledge gap, we tested five venoms-, , (Turkmenistan and Uzbekistan localities), and -using plasma clotting assays, Factors VII, X, XI, and XII and prothrombin zymogen activation assays, and SDS-PAGE to visualise Factor V (FV) cleavage. All venoms induced extremely rapid clot formation (10.
View Article and Find Full Text PDFJ Mol Neurosci
July 2025
Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Menoufia Governate, El-Sadat, Egypt.
Stroke is the second leading cause of death globally and a major contributor to disability. Developing countries report the highest rates of stroke, with ischemic stroke being the most prevalent type. This study aimed to explore the potential association between specific single nucleotide polymorphisms (SNPs) and thrombotic strokes in Egyptian patients, as well as the role of DNA methylation in the promoter regions of genes associated with these SNPs.
View Article and Find Full Text PDFCureus
June 2025
Department of Urology, Jefferson Health, Stratford, USA.
Introduction Minimally invasive surgery (MIS), such as laparoscopic and robotic techniques, has become standard in kidney surgery due to its benefits in offering faster recovery while maintaining comparable oncologic outcomes when compared to open surgery. However, some cases still require unexpected conversion to open surgery, which can increase the risk of postoperative complications and increase the 30-day readmission risk. Predictors and risk factors for these conversions remain underexplored.
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