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http://dx.doi.org/10.1111/jfb.15880 | DOI Listing |
EBioMedicine
August 2025
Department of Neurosurgery and Oncology, Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, 1650 Orleans St., Baltimore, MD, 21231, USA; Johns Hopkins All Children's Hospital, 600 5th St. South, St. Petersburg, FL, 33701, USA. Electronic address:
Background: Prostate cancer (PCa) is one of the leading causes of cancer death in men. While prostate-specific antigen (PSA) testing is widely used for screening, its diagnostic accuracy is limited, often failing to distinguish between benign and malignant prostate conditions, underscoring the need for novel biomarkers with improved diagnostic performance. This study aimed to identify and validate a panel of urinary RNA biomarkers with improved diagnostic accuracy for PCa.
View Article and Find Full Text PDFPurpose: Perineural invasion (PNI) and lymphovascular invasion (LVI) represent tumor escape mechanisms at radical prostatectomy (RP). We assessed their prognostic significance for biochemical recurrence (BCR) following complete resection.
Methods: We analyzed 10,471 men with negative surgical margins after RP, stratified into three groups based on pathological PNI and LVI status: Group 1 (PNI-/LVI-, n = 1,925), Group 2 (PNI+/LVI-, n = 7,849), and Group 3 (LVI+, n = 697; 14 with PNI-/LVI + and 683 with PNI+/LVI+).
Nat Rev Urol
September 2025
Department of Urology, Rush University Medical Center, Chicago, IL, USA.
The advent of the purpose-built da Vinci single-port robotic platform marks a pivotal advancement in minimally invasive urological surgery. Designed to overcome the ergonomic and technical limitations of prior single-site approaches, the single-port system enables complex procedures through a single incision, with enhanced dexterity, optimized use of confined spaces and improved cosmetic and peri-operative outcomes. The single-port system has been increasingly used across a wide range of urological indications, including robot-assisted radical prostatectomy, partial nephrectomy, nephroureterectomy and reconstructive surgeries such as pyeloplasty and ureteral re-implantation.
View Article and Find Full Text PDFReprod Biomed Online
August 2025
London Women's Clinic, London, UK.. Electronic address:
Few people have a lasting impact after their death. There are artists whose images resonate for generations, writers whose words continue to speak beyond a lifetime. Scientists too achieve that distinction, not in their creative appeal but in the living legacy they leave to the people behind.
View Article and Find Full Text PDFJAMA
August 2025
Department of Cardiology, Zuyderland Medical Centre, Heerlen, the Netherlands.
Importance: The benefits of fractional flow reserve (FFR)-guided complete coronary revascularization in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease remain unclear.
Objective: To compare FFR-guided complete revascularization of nonculprit lesions vs culprit-only revascularization in patients with NSTEMI and multivessel disease.
Design, Setting, And Participants: This prospective, investigator-initiated, multicenter, international randomized clinical trial was conducted at 9 hospitals in Europe.