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http://dx.doi.org/10.1016/j.jcin.2024.06.019 | DOI Listing |
J Neuroeng Rehabil
July 2025
Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong Province, 519090, China.
Background: Targeted Muscle Reinnervation (TMR) improves real-time control of EMG-based prostheses by connecting severed nerves to adjacent muscles, creating new EMG signals. However, TMR requires cutting original nerve connections, which can cause denervation atrophy and limit functional recovery. As an alternative, Targeted Nerve Function Replacement (TNFR) offers a fundamentally different approach by establishing a direct end-to-end anastomosis between an intact donor nerve and the original nerve of a target muscle, preserving existing neural pathways while providing supplementary neural input.
View Article and Find Full Text PDFBMC Public Health
June 2025
Department of Clinical Sciences, Pediatrics, Umeå University, 901 85, Umeå, Sweden.
Background: Non-communicable diseases (NCDs) are a global health issue, posing a substantial burden on the individual, community, and public health. The risk of developing NCDs is influenced by a complex interplay between genetic, epigenetic, and environmental factors.
Methods: The NorthPop Birth Cohort Study (NorthPop) constitutes an infrastructure enabling cutting-edge research on the foundational pathways to NCDs in childhood, including allergic diseases and asthma, overweight/obesity, cognitive and neurodevelopmental dysfunction, gastrointestinal disorders, and caries.
J Control Release
August 2025
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital, Department of Pharmacy, School of Medicine, Tongji University, Shanghai, China. Electronic address:
Therapeutic strategies targeting iron metabolism to disturb the physiological functions of tumor cells have emerged as promising avenues in cancer treatment. Deferoxamine (DFOM) is an effective FDA-approved iron chelator that actively eliminates iron from cells, inducing iron-related dysfunction. However, its use is considerably limited by off-target toxicities and the innate metabolic compensatory capacity of tumor cells.
View Article and Find Full Text PDFInt J Mol Sci
May 2025
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Spinal cord injury (SCI) is a debilitating neurological condition that leads to severe disabilities, significantly reducing patients' quality of life and imposing substantial societal and economic burdens. SCI involves a complex pathogenesis, including primary irreversible damage and secondary injury driven by neuroinflammation, apoptosis, and ischemia. Current treatments often provide limited efficacy, underscoring the urgent need for innovative therapeutic strategies.
View Article and Find Full Text PDFRespirology
June 2025
Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Infection, Immunity & Respiratory Medicine, The University of Manchester, Manchester, UK.
Background And Objective: Non-pharmacological intervention is the recommended gold standard for inducible laryngeal obstruction (ILO) treatment. Despite this, there is no standardised approach and interventions are poorly described. The objective was to develop and describe a standardised non-pharmacological intervention for ILO, for future testing of effectiveness.
View Article and Find Full Text PDF